DR. HECTOR AUGUSTO BATTIFORA, M.D.
Medical Practice at Wilson Ave, Arcadia, CA

5002377, Mar 26, 1991

Jul 7, 1988

7/216676

Hector A. Battifora - Arcadia CA
Parula Mehta - Glendora CA

City of Hope - Duarte CA

G01N 2101, G01N 100, G02B 2134

350535

A process for producing a slide bearing a spaced array of specimen fragments which comprises (i) cutting at least one specimen into a plurality of narrow strips; (ii) separating the plurality into groups of specimen strips; (iii) separately positioning strips from the groups in parallel grooves in a mold; (iv) embedding the strips in the mold in a first embedding medium to provide a structure comprising a base member having opposed first and second surfaces, the first surface being substantially planar; the second surface having ridges containing a specimen strip extending therefrom; (v) forming a stack of elements, each element corresponding to the structure, with the terminal surface of the ridges of an upper structure abutting the substantially planar first surface of the next lower structure; the spaces between the ridges defining channels for receipt of a fluid; (vi) embedding the stack in a second embedding medium to form a block having a spaced array of parallel specimen strips embedded therein; the strips being so arranged that a section of the block includes a spaced array of cross-sections of each of the embedded specimen strips; (vii) dividing the block into sections each containing a spaced array of cross-sections of each of the embedded specimen strips; (viii) mounting at least one of such block sections on a slide.

5610022, Mar 11, 1997

Jun 8, 1993

8/073669

Hector A. Battifora - Arcadia CA

City of Hope - Duarte CA

G01N 3353, G01N 33574

435 723

An internal control or standard is provided for the direct quantitative assay by immunocytochemistry of target molecules in tissue specimens and the like. The control may be subjected to the same conditions including immunostaining as the tissue specimen. Immunoreactivity of the control and the specimen before and after processing is compared by physical measurement, e. g. , optical density as determined by a cell analysis computer system. The immunoreactivity difference of the control provides a quantative standard useful to determine the effect of the processing on the immunoreactivity of the specimen.

4820504, Apr 11, 1989

Feb 6, 1987

7/011689

Hector A. Battifora - Arcadia CA

City of Hope - Duarte CA

G01N 128, G01N 33531, G01N 33577

424 3

A method of preparing a multi-specimen tissue block, and sections thereof, comprising forming a plurality of different antigenically reactive tissue specimens into rods having a relatively small cross-sectional area and a relatively great length, disposing the rods in a substantially parallel relationship on a casing, wrapping the rods in the casing, embedding the wrapped rods in an embedding medium to form a tissue block in which the rods are perpendicular to the face of the block, and dividing the block into sections which each contain a cross-section of each of the rods.