Inventors:
Thomas Van Dyke - West Roxbury MA, US
Michael Holick - Sudbury MA, US
Hatice Hasturk - Brighton MA, US
International Classification:
A61K 31/415, A61K 31/425, A61P 43/00
US Classification:
514369000, 514365000, 514396000
Abstract:
The present invention provides methods for treating or preventing periodontal disease in a mammal subject. The inventive methods comprise topically administering to the subject an effective amount of a H2 antagonist encapsulated in liposomes. Preferably, the H2 antagonist, for example, Cimetidine, is encapsulated into paucilamellar liposomes, such as Novasome® microvesicles. The inventive methods may be used to treat and/or prevent gingivitis, periodontitis, aphthous ulcers, or herpetic stomatitis. Alternatively, the inventive methods may be used to treat and/or prevent a systemic disease associated with periodontal disease, such as cardiovascular diseases, pregnancy complications, and diabetes.