HARRIS GOLDSTEIN, MD
Osteopathic Medicine at Bainbridge Ave, Bronx, NY

6563014, May 13, 2003

Dec 14, 1999

09/460555

Harris Goldstein - Teaneck NJ
Jessie Browning Paul - New York NY

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

A01K 67027

800 3, 800 18, 800 8, 800 9, 800 11

Transgenic non-human animals are described comprising a transgene for a species-specific pathogen and transgene(s) for at least one receptor restricting infection of the pathogen to the host species. Also described is a method for creating the transgenic non-human animal of this invention and a method for screening an agent for the ability to inhibit infection by a species-specific virus using said transgenic non-human animal. The transgenic animal of this invention has a sustained productive viral infection and does not develop a virus-specific immune response, thereby resulting in an extremely useful self-contained system to investigate the factors modulating in vivo replication of human pathogens, the pathophysiological effect of pathogen replication and production, and the effectiveness of novel therapies and vaccines modifying or inhibiting the course of pathogenesis.

2008022, Sep 18, 2008

Mar 6, 2006

11/885769

Ekaterina Dadachova - Mahopac NY, US
Arturo Casadevall - New Rochelle NY, US
Harris Goldstein - Teaneck NJ, US

A61K 51/10, A61P 31/18

424 149

This invention provides methods for treating subjects infected with human immunodeficiency virus (HIV) which comprise administering to the subjects a radiolabeled antibody or agent effective to kill HIV infected cells, where the antibody or agent is specific for a HIV envelope glycoprotein. The invention also provides compositions and methods for making compositions of radiolabeled antibodies or agents to HIV envelope glycoproteins for treatment of HIV infection.

5811635, Sep 22, 1998

Oct 29, 1996

8/739281

Harris Goldstein - Bronx NY
Tobias R. Kollmann - Bronx NY

Albert Einstein College of Medicine of Yeshiva University, a Division of
Yeshiva University - Bronx NY

C12N 1500, A01N 6300

800 2

This invention is directed to a chimeric mouse capable of mounting murine cellular and humoral immune response, said chimeric mouse being tolerant of human tissue implanted therein. The chimeric mouse of this invention is capable of developing murine T cells and producing murine IgG antibodies, which T cells and antibodies are tolerant of the human tissue implanted in said mouse, thereby allowing for the challenge of said vaccinated mouse with human-specific pathogens and determining the capacity of the vaccine to protect the cells in said implanted tissue from infection. This invention is also directed to a method for the development of said chimeric mouse, as well as to the use of said chimeric mouse for the screening of vaccines for human-specific pathogens.

6054116, Apr 25, 2000

Jul 15, 1998

9/115424

Harris Goldstein - Bronx NY
Tobias R. Kollmann - Bronx NY

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

C12N 510, A61K 4900

424 92

This invention is directed to a chimeric mouse capable of mounting murine cellular and humoral immune response, where the chimeric mouse is tolerant of human tissue implanted therein. The chimeric mouse of this invention is capable of developing murine T cells and producing murine IgG antibodies, which T cells and antibodies are tolerant of the human tissue implanted in the mouse. This allows for the challenge of the vaccinated mouse with human-specific pathogens and determining the capacity of the vaccine to protect the cells in the implanted tissue from infection. This invention is also directed to a method for the development of the chimeric mouse, as well as to the use of the chimeric mouse for the screening of vaccines for human-specific pathogens.