Inventors:
Markus Meyer - Randolph VT, US
Martin M. LeWinter - Williston VT, US
Harold L. Dauerman - Shelburne VT, US
Stephen P. Bell - Milton VT, US
Assignee:
University Of Vermont and State Agricltural College - Burlington VT
International Classification:
A61K 49/00, A61P 9/10, A61P 9/14, A61P 13/12, A61P 39/06
Abstract:
The invention relates in some aspects to compositions that include a contrast agent and an antioxidant compound and the use of such compositions to prevent (e.g., reduce) organ damage in a subject. In some aspects, the invention relates to compositions that include N— acetylcysteine (NAC) and a contrast agent and the use of such compositions for preventing organ damage in a subject. Methods of preventing organ damage may include the simultaneous administration of a composition of the invention, such that a contrast agent and an antioxidant compound or a contrast agent and NAC are administered intravascularly to a subject. Examples of organ damage that may be treated with compositions and methods of the invention include contrast-induced and non-contrast induced organ damage associated with myocardial ischemia, myocardial infarction, reperfusion damage, nephropathy, etc. The invention, in some aspects, also includes kits that may include a contrast agent and NAC and/or an antioxidant compound.