Harold Joseph Wanebo
Physician at Post Rd, Warwick, RI
License number
Colorado 14044
Issued Date
Apr 15, 1963
Renew Date
May 31, 1989
Expiration Date
May 31, 1989
Type
Physician
Address
Address
3595 Post Rd, Warwick, RI 02886
Professional information
Combinations Of Ceramide And Chemotherapeutic Agents For Inducing Tumor Cell Death
US Patent:
7015251, Mar 21, 2006
Filed:
Apr 7, 2000
Appl. No.:
09/958453
Inventors:
Harold J. Wanebo - East Greenwich RI, US
Shashikant Mehta - Warwick RI, US
Shashikant Mehta - Warwick RI, US
Assignee:
Roger Williams Hospital - Providence RI
International Classification:
A61K 31/16, A61K 33/24
US Classification:
514627, 424649
Abstract:
This invention provides a method for increasing apoptosis in tumor cells and a method of decreasing a size of a tumor, said methods comprising contacting the tumor cells with: a) an effective amount of at least one antitumor chemotherapeutic agent and b) an effective amount of a ceramide, sequentially or concomitantly, wherein the apoptosis induced by the combination of the antitumor chemotherapeutic agent and the ceramide is greater than the apoptosis induced by contact of the tumor cells with either the antitumor chemotherapeutic agent alone or the ceramide alone. This invention also provides a method of treating cancer in a subject which comprises a method according to either of the above-described methods. This invention provides a method for treating cancer in a subject comprising administering to the subject an effective amount of at least one antitumor chemotherapeutic agent and an effective amount of at least one ceramide, sequentially or concomitantly. This invention provides a pharmaceutical composition comprising at least one antitumor chemotherapeutic agent in an amount effective to induce apoptosis of tumor cells and at least one ceramide in an amount effective to induce apoptosis of tumor cells and a pharmaceutically acceptable carrier.
Combinations Of Ceramide And Chemotherapeutic Agents For Inducing Cell Death And Uses Thereof In Treating Cancer
US Patent:
7820718, Oct 26, 2010
Filed:
Apr 7, 1999
Appl. No.:
09/287884
Inventors:
Harold J. Wanebo - East Greenwich RI, US
Shashikant Mehta - Warwick RI, US
Shashikant Mehta - Warwick RI, US
Assignee:
Roger Williams Hospital - Providence RI
International Classification:
A61K 31/16
US Classification:
514629, 514449
Abstract:
This invention provides a method for increasing apoptosis in tumor cells and a method of decreasing a size of a tumor, said methods comprising contacting the tumor cells with: a) an effective amount of at least one antitumor chemotherapeutic agent and b) an effective amount of a ceramide, sequentially or concomitantly, wherein the apoptosis induced by the combination of the antitumor chemotherapeutic agent and the ceramide is greater than the apoptosis induced by contact of the tumor cells with either the antitumor chemotherapeutic agent alone or the ceramide alone. This invention also provides a method of treating cancer in a subject which comprises a method according to either of the above-described methods. This invention provides a method for treating cancer in a subject comprising administering to the subject an effective amount of at least one antitumor chemotherapeutic agent and an effective amount of at least one ceramide, sequentially or concomitantly. This invention provides a pharmaceutical composition comprising at least one antitumor chemotherapeutic agent in an amount effective to induce apoptosis of tumor cells and at least one ceramide in an amount effective to induce apoptosis of tumor cells and a pharmaceutically acceptable carrier.