Harold C Nielson
Pharmacy in Salt Lake City, UT
License number
Utah 103038-8912
Issued Date
Dec 30, 1992
Expiration Date
Dec 31, 1994
Category
Pharmacy
Type
Limited Controlled Substance-Individual
Address
Address
Salt Lake City, UT
Professional information
Immunomodulatory Activity Of Exogenous Melatonin Following Traumatic Injury
US Patent:
5519047, May 21, 1996
Filed:
Apr 20, 1994
Appl. No.:
8/230543
Inventors:
Jane Shelby - Park City UT
Harold C. Nielson - Salt Lake City UT
Harold C. Nielson - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A61K 3140
US Classification:
514419
Abstract:
A method of decreasing elevated levels of IL-6 and. gamma. -IFN that are secreted in response to traumatic injury in a warm-blooded animal is disclosed, comprising the step of administering an effective amount of melatonin to the animal. The melatonin should be administered so as to provide a peak amount of circulating melatonin at a time in the animal's daily cycle when endogenous melatonin reaches peak amounts. Elevated levels of IL-6 and. gamma. -IFN are also decreased by exposing the animal to certain daily regimens of light and dark, such as 24 hours of dark. Cell-mediated immune response to a contact antigen is also enhanced by administration of exogenous melatonin.