Inventors:
Hara Levy - Bayside WI, US
Craig Gerard - Chestnut Hill MA, US
Gerald Pier - Brookline MA, US
Scott Weiss - Chestnut Hill MA, US
Christoph Lange - Cambridge MA, US
International Classification:
A61K 39/395, A61P 31/04, A61P 29/00, A61P 31/00, A61K 38/16, A61K 31/555
Abstract:
Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful in predicting CF disease progression and assessing a CF subject's response to therapy.