Inventors:
Han Win Tun - Jacksonville FL, US
Simon James Cooper - Jacksonville FL, US
Laura Ann Marlow - Jacksonville FL, US
Assignee:
Celgene Corporation - Summit NJ
International Classification:
A61K 38/00, C12Q 1/68, G01N 33/574, A61K 31/706
US Classification:
514 199, 435 612, 435 792, 435 74
Abstract:
Methods of treating, preventing or managing triple negative breast cancer (TNBC) or clear cell renal cell carcinoma (ccRCC) are disclosed. The methods encompass the administration of an HDAC inhibitor romidepsin in combination with a cytidine analog. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.