Inventors:
Pomila Singh - Houston TX, US
Gurpreet Singh - Houston TX, US
International Classification:
A61K 9/127, A61K 9/14, A61K 39/395, A61K 47/00, C12N 5/02, A61K 38/00, A61K 31/7088, A61P 35/00
US Classification:
424450, 424484, 4241301, 4242781, 435375, 514 11, 514 193, 514 44 A
Abstract:
The present invention is drawn to immunotherapeutic methods to treat tumors/cancers that produce progastrin ectopically or are dependent on progastrin for their growth. Disclosed herein are immunogenic compositions comprising agents that target progastrin, agents that target the progastrin receptor, annexin II, or both. Such a composition may be administered in combination with chemotherapy or to an individual who had been previously subjected to chemotherapy or radiation therapy. The cancers that may be treated using such a composition may include but are not limited to colon cancer, breast cancer, lung cancer or pancreatic cancer.