Inventors:
Jean-Pierre Raufman - Baltimore MD, US
Kunrong Cheng - Cockeysville MD, US
Jasleen Shant - Elkridge MD, US
Guofeng Xie - Baltimore MD, US
Sandeep Khurana - Columbia MD, US
Assignee:
University of Maryland, Baltimore - Baltimore MD
International Classification:
A61K 39/395, A61P 35/00, A61K 31/7088, A01K 67/027, A61K 31/713
Abstract:
The present invention relates to methods of treating proliferative disorders of colon cells. The methods comprise administering to the cells an effective amount of at least one agent to reduce M3 muscarinic receptor-mediated transactivation of at least one epidermal growth factor receptor.