Inventors:
Robert E. Dempski - Dresher PA
Gunvant N. Mehta - Lansdale PA
Joseph C. Saboe - Norristown PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 922, A61K 948
Abstract:
A sustained release indomethacin pharmaceutical product is provided that utilizes a pellet formulation encapsulated in a hard gelatin capsule. A portion of the pellets is uncoated for immediate and rapid release of indomethacin for elevating the plasma level. The remainder of the pellets are coated with a polymer to sustain the plasma level. The uncoated and coated pellets may be mixed with non-medicated pellets as a capsule filler.