Va Eastern Colorado Health Care System(Echcs) 1055 Clermont St, Denver, CO 80220Cheyenne Va Medical 2360 E Pershing Blvd, Cheyenne, WY 82001Sheridan Vamc 1898 Fort Rd, Sheridan, WY 82801
Protease Inhibition For Prevention Or Treatment Of Heart Failure
US Patent:
7862811, Jan 4, 2011
Filed:
Feb 25, 2005
Appl. No.:
11/066839
Inventors:
Clifford Greyson - Greenwood Village CO, US Gregory Schwartz - Denver CO, US
Assignee:
Regents of the University of Colorado - Boulder CO
International Classification:
A61K 38/43
US Classification:
424 941
Abstract:
Methods, and compositions to prevent and/or treat acute or chronic right ventricular failure from pressure over load (RVPO). In one embodiment, the method includes the inhibition of at least one cysteine protease. In other embodiments, the method includes the inhibition of MMP activity to prevent or treat right ventricular failure from acute pressure over load (RVPO). In another embodiment, combination therapies are included to inhibit cysteine protease activity and MMP activity.