Inventors:
ROBERT A. LAZZARINI - NEW YORK NY, US
GREGORY ELDER - NEW YORK NY, US
International Classification:
A01K067/027, A01K067/033
US Classification:
800/003000, 800/012000, 800/013000, 800/014000, 800/018000, 800/021000, 800/024000, 800/025000
Abstract:
The present invention provides for genetically engineered non-human animals, including but not limited to mice, which lack one or more endogenous neurofilament gene. Human neurofilament genes may be introduced into such genetically non-human animals (referred to hereafter as “knockout animals”) to produce improved models of the physiology of human neurofilament proteins which may be used to study human neurofilament-associated neurodegenerative conditions.