Inventors:
Gregory A. Grabowski - Cincinnati OH, US
Hong Du - Cincinnati OH, US
International Classification:
A61K 38/46, A61P 9/10, A61P 9/00, A61K 31/7088, C12N 15/09
US Classification:
424 946, 514 44 R, 435455
Abstract:
The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or on the cell which lead to uptake into the lysosome. Such substances used to diminish and/or eliminate atherosclerotic plaques are generally comprised of lipid hydrolyzing proteins and/or polypeptides.