Inventors:
Stephen L. Warren - Fort Collins CO, US
Gregory A. Gould - Wrentham MA, US
Kevin Lillehei - Englewood CO, US
International Classification:
A61K 51/12, A61K 9/00, A61P 35/00, A61K 49/06
US Classification:
424 111, 424423, 424426, 424 93
Abstract:
A filament comprising a biocompatible material and a bioactive agent, adapted for implantation within the tissue of a patient wherein the bioactive agent is released over a period of time, is provided. An array of a plurality of the filaments implanted within the tissue of a patient, an array assembler, and a matrix comprising a plurality of filaments and a base adapted for implantation within the tissue of a patient, are further provided. A method for treatment of a malcondition in a patient comprises implantation of a filament, an array of filaments, or a matrix. The bioactive agent can be a chemotherapeutic agent or a radiotherapeutic agent. A radiotherapeutic agent is 123I- or 125I-IUDR, for example in treatment of an advanced stage localized brain tumor such as glioblastoma multiforme.