GOWTHAMI AREPALLY, MD
Osteopathic Medicine in Durham, NC
License number
North Carolina 2001-01519
Category
Osteopathic Medicine
Type
Hematology
Address
Address
Duke University Medical Ctr, Durham, NC 27710
Phone
(919) 620-4467
Personal information
See more information about GOWTHAMI AREPALLY at radaris.comName
Address
Phone
43 Beverly Dr, Durham, NC 27707
Durham, NC
1515 Hermitage Ct, Durham, NC 27707
43 Beverly Dr, Durham, NC 27707
Organization information
See more information about GOWTHAMI AREPALLY at bizstanding.comGowthami Arepally MD
1000 Trent Dr, Durham, NC 27710
Industry:
Internist
Phone:
(800) 266-3853 (Phone)
Gowthami Morey Arepally
Gowthami Arepally MD
201 Trent Dr Mc 3422, Durham, NC 27707
Categories:
Hematology Physicians & Surgeons
Phone:
(919) 684-5350 (Phone)
Professional information
Compositions And Methods Useful For The Diagnosis And Treatment Of Heparin Induced Thrombocytopenia/Thrombosis
US Patent:
7728115, Jun 1, 2010
Filed:
Aug 2, 2005
Appl. No.:
11/195095
Inventors:
Gowthami M. Arepally - Durham NC, US
Walter Kisiel - Albuquerque NM, US
Keiko Kamei - Kumamoto, JP
Shintaro Kamei - Kumamoto, JP
Walter Kisiel - Albuquerque NM, US
Keiko Kamei - Kumamoto, JP
Shintaro Kamei - Kumamoto, JP
Assignee:
STC. UNM - Albuquerque NM
International Classification:
C07K 16/18, C12P 21/08, G01N 33/564, G01N 33/577, C12N 5/20
US Classification:
5303887, 435 724, 435 691, 435 7021, 435452, 435332, 435337, 435975, 436506, 436512, 436548, 5303873, 53038825, 530866
Abstract:
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of heparin induced thrombocytopenia/thrombosis (HIT/HITT) in a mammal. The monoclonal antibody of the invention preferentially binds with a PF4/heparin complex relative to the binding of the antibody with PF4 or heparin alone. The monoclonal antibody of the invention also binds specifically with PF4 in a complex with other glycosaminoglycans besides heparin, and also activates platelets. The monoclonal antibody of the invention is useful in methods for diagnosing and treating HIT/HITT in a mammal. A humanized version of the monoclonal antibody of the invention is also included, along with a process for humanizing the monoclonal antibody of the invention.
Gowthami Arepally, Durham NC
Specialties:
Pediatrics, Pediatric Hematology-Oncology, Internal Medicine, Hematology, Hematology & Oncology, Medical Oncology, Hematology
Work:
Durham Va Medical Center
508 Fulton St, Durham, NC 27705 Private Diagnostic Clinic
1000 Trent Dr, Durham, NC 27710
508 Fulton St, Durham, NC 27705 Private Diagnostic Clinic
1000 Trent Dr, Durham, NC 27710
Education:
Vanderbilt University (1989)
Dr. Gowthami Arepally, Durham NC - MD (Doctor of Medicine)
Specialties:
Hematology, Medical Oncology, Oncology
Address:
Durham Office
1 Duke Medical Ctr, Durham 27710
(919) 684-8111 (Phone), (919) 681-8679 (Fax)
Duke Medical Center Hematology
201 Trent Dr SUITE MC3422, Durham 27710
(919) 684-5350 (Phone)
1 Duke Medical Ctr, Durham 27710
(919) 684-8111 (Phone), (919) 681-8679 (Fax)
Duke Medical Center Hematology
201 Trent Dr SUITE MC3422, Durham 27710
(919) 684-5350 (Phone)
Certifications:
Hematology, 1996, Internal Medicine, 1992, Medical Oncology, 1997
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Vanderbilt University
Graduated: 1989
Vanderbilt University
Graduated: 1989
Gowthami M Arepally, Durham NC
Specialties:
Hematologist
Address:
Duke University Medical Ctr, Durham, NC 27710
Education:
Doctor of Medicine
Board certifications:
American Board of Internal Medicine Sub-certificate in Hematology (Internal Medicine)
Platelet Surface Pf4 Antigenic Complexes As A Diagnostic Indicator In Heparin-Induced Thrombocytopenia
US Patent:
2007019, Aug 16, 2007
Filed:
Dec 20, 2006
Appl. No.:
11/613787
Inventors:
Mortimer Poncz - Philadelpia PA, US
Douglas Cines - Wynnewood PA, US
Gowthami Arepally - Durham NC, US
Lubica Rauova - Philadelpia PA, US
Douglas Cines - Wynnewood PA, US
Gowthami Arepally - Durham NC, US
Lubica Rauova - Philadelpia PA, US
International Classification:
G01N 33/567
US Classification:
435007210
Abstract:
A method for diagnosing a predisposition for developing HIT is provided.