GORDON LEWIS AMIDON
Pharmacy in Ann Arbor, MI

5976571, Nov 2, 1999

Oct 7, 1997

8/946515

John R. Crison - Ann Arbor MI
Gordon L. Amidon - Ann Arbor MI

Port Systems, L.L.C. - Ann Arbor MI

A61K 922

424472

A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) for containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system (10) and method by which the drug delivery system (10) provides the drug to a body.

6207191, Mar 27, 2001

Aug 12, 1999

9/372913

John R. Crison - Ann Arbor MI
Gordon L. Amidon - Ann Arbor MI

Port Systems, L.L.C. - Ann Arbor MI

A61K9/22

424472

A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system (10) and method by which the drug delivery system (10) provides the drug to a body.

5569452, Oct 29, 1996

May 30, 1995

8/453438

Gordon L. Amidon - Ann Arbor MI
Lizbeth B. Sherman - Ann Arbor MI
John R. Crison - Ann Arbor MI

TSRL, Inc. - Ann Arbor MI

A61K 3174, B29C 4900

424 781

A pharmaceutical formulation comprising a polymeric resin having bile acid binding properties in combination with at least one bile acid binding material which enhances the bile acid binding affinity and/or capacity of the formulation, methods for preparing the formulations and methods for using the formulations.

5221698, Jun 22, 1993

Jun 27, 1991

7/722511

Gordon L. Amidon - Ann Arbor MI
Ramachandran Chandrasekharan - Ypsilanti MI
Arthur H. Goldberg - Montclair NJ

The Regents of the University of Michigan - Ann Arbor MI

C08J 702, B05D 300

523122

An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and polymer are essentially dissolved in the solvent system to form a sprayable composition having a viscosity of less than 350 cP. Upon dilution with water, the viscosity of the composition increases to in excess of 1,000 cP to produce a retentive coating at the site of application which provides enhanced bioavailability of the agent.

6153592, Nov 28, 2000

Sep 8, 1994

8/244715

Gordon L. Amidon - Ann Arbor MI
Glen D. Leesman - Hamilton MT
Patrick J. Sinko - Lebanon NJ

Port Systems, LLC - Ann Arbor MI

A61K 3823, A61K 3816

514 21

Proteins or peptidic substances, which may be prepared from naturally occurring proteins, enhance the bioavailability of proteolytically-labile therapeutic agents which, in the absence of the protein or peptidic substance would suffer enzymatic inactivation upon administration.

5993858, Nov 30, 1999

Jun 13, 1997

8/867161

John R. Crison - Ann Arbor MI
Gordon L. Amidon - Ann Arbor MI

Port Systems L.L.C. - Ann Arbor MI

A61K 910

424490

A self-microemulsifying excipient formulation for increasing the bioavailability of a drug which includes an emulsion including an oil or other lipid material, a surfactant, and a hydrophilic co-surfactant. A method for making a drug delivery system for increasing the bioavailability of a drug by emulsifying at least one drug with a self-microemulsifying excipient comprising an oil or other lipid material, a surfactant, and a hydrophilic co-surfactant and drugs formulated thereby.

5851275, Dec 22, 1998

Jan 27, 1997

8/790737

Gordon L. Amidon - Ann Arbor MI
John R. Crison - Ann Arbor MI

Port Systems, L.L.C. - Ann Arbor MI

C08H 100, C08L 8900

1061481

A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.

5387421, Feb 7, 1995

May 31, 1994

8/251731

Gordon L. Amidon - Ann Arbor MI
Glen D. Leesman - Ann Arbor MI
Lizbeth B. Sherman - Ann Arbor MI

TSRL, Inc. - Ann Arbor MI

A61K 922

424472

A drug delivery system includes a first capsule half having an inner chamber for containing a drug therein. A plug is disposed in a passageway of the capsule half for plugging the opening thereof. The plug is releasable from the passageway opening upon the application of pressure from within the inner chamber. A pump mechanism causes an increase in pressure within the inner chamber and forces the plug out of the passageway to release the drug from the inner chamber and out of the passageway thereby providing a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system and method by which the drug delivery system provides the drug to the body.

6048551, Apr 11, 2000

Mar 27, 1997

8/824997

John M. Hilfinger - Ann Arbor MI
Beverly L. Davidson - Iowa City IA
Steven J. Beer - Iowa City IA
John R. Crison - Ann Arbor MI
Gordon L. Amidon - Ann Arbor MI

A61K 950, A61F 202, B01J 1302, B32B 516

424501

A controlled release delivery system includes a functional gene vector in a biodegradable polymeric microsphere encapsulating the vector. The present invention further provides a method of making a controlled release delivery system by encapsulating the functional gene vector in a biologically degradable polymeric microsphere.

5834022, Nov 10, 1998

Jan 29, 1997

8/790570

Gordon L. Amidon - Ann Arbor MI
John R. Crison - Ann Arbor MI

Port Systems L.L.C. - Ann Arbor MI

A61K 914, A61K 916

424492

A method of making a pharmaceutical composition is disclosed. The method includes the steps of contacting at least one pharmaceutical ingredient with a mixture consisting essentially of gelatin and lecithin to increase the dissolution rate of water-insoluble pharmaceutical ingredients. A pharmaceutical excipient coating for increasing the dissolution rate of water-insoluble pharmaceutical ingredients is also disclosed. The coating consists essentially of gelatin and lecithin.