Inventors:
Jennifer Jones McIntire - Palo Alto CA, US
Rosemarie Dekruyff - Newton MA, US
Dale T. Umetsu - Newton MA, US
Gordon Freeman - Boston MA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
Dana-Farber Cancer Institute - Boston MA
International Classification:
C12Q 1/68, C12P 19/34, C07H 21/04
US Classification:
435 6, 435 911, 536 243, 436 63
Abstract:
A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.