Inventors:
Steven Quay - Woodinville WA, US
Gordon Brandt - Issaquah WA, US
Mary Kleppe - Snohomish WA, US
Conor MacEvilly - Seattle WA, US
International Classification:
A61K 38/22, A61K 31/70, A61K 31/7012, A61K 31/715, A61K 31/045, A61K 31/724
US Classification:
514012000, 514054000, 514058000, 514023000, 514061000, 514053000, 604500000, 514738000
Abstract:
A pharmaceutical device comprising a composition comprising an aqueous solution of PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation, and wherein the composition is present in a container; and an actuator fluidly connected to the container, wherein the actuator has a tip which defines a passage through which the solution is ejected to produce a spray of the solution.