GLENN H BOCK
Medical Practice at Hoover St, Bethesda, MD

License number

DC MD12816

Issued Date

Jan 1, 1901

Expiration Date

Dec 31, 2004

Professional information

Monoclonal Antibody Recognizing A Surface Molecule On A Subset Of Antigen-Stimulated T Cells And On Certain Malignancies Of T And B Cell Origin

US Patent:

5556947, Sep 17, 1996

Filed:

Aug 9, 1994

Appl. No.:

8/287718

Inventors:

Glenn H. Bock - Bethesda MD
David L. Nelson - Bethesda MD
Carole C. Kurman - Potomac MD
Thomas A. Fleisher - Bethesda MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

A61K 39395, C07K 1618, C07K 1628

US Classification:

5303913

Abstract:

This invention provides an IL-6 dependent B-cell lymphoma cell line designated DS-1 deposited with the American Type Culture Collection, wherein the cell line is reactive with a monoclonal antibody produced by a hybridoma cell line designated 10D2F6 deposited with the American Type Culture Collection. The invention also provides a purified antigen reactive with a monoclonal antibody produced by 10D2F6. The antigen also exists on DS-1. Also provided is a method of detecting the presence of an antigen-stimulated T-cell comprising detecting the presence of the antigen on a lymphocyte. In addition, the invention provides a method of detecting the presence of a neoplastic cell comprising detecting the presence of the antigen on a cell which is not normal a T-cell.