Inventors:
Gary D. Glick - Ann Arbor MI, US
Gina Ney - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 31/4196, C07D 233/90, A61K 31/4164, C07D 249/08, A61P 31/04, A61P 35/00, A61P 9/10, A61P 37/02
US Classification:
514383, 5483365, 514400, 5482674
Abstract:
The present invention relates to a family of guanidine-based F1F0-ATPase inhibitors, e.g., mitochondrial F1F0-ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders.