Ghaleb Adnay Husseini
Engineers in Provo, UT
License number
Utah 343809-2202
Category
Engineer/Land Surveyor
Type
Professional Engineer
Address
Address
Provo, UT
Professional information
Technique For Drug And Gene Delivery To The Cell Cytosol
US Patent:
2011010, May 5, 2011
Filed:
Nov 5, 2010
Appl. No.:
12/940047
Inventors:
William G. Pit - Orem UT, US
Ghaleb Husseini - Provo UT, US
Ghaleb Husseini - Provo UT, US
Assignee:
Brigham Young University - Provo UT
International Classification:
A61K 9/127, C12N 5/071, A61K 31/713, A61K 31/711, A61K 38/02, A61K 38/43, A61K 31/7105, C12N 13/00, A61P 35/00, A61P 29/00, A61P 19/02, B82Y 5/00
US Classification:
424450, 435375, 514 44 A, 514 44 R, 514 11, 424 941, 4351731, 977773, 977907
Abstract:
Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the group consisting of endocytosis, pinocytosis or phagocytosis, the liposome comprising a phase transforming liquid with vapor pressure capable of forming a gas at low pressure, said liquid being associated with the liposome, and the liposome further comprising at least one functional molecule selected from the group consisting of a therapeutic molecule, a detectable label, and a targeting molecule.