GERMAN FELIX LEPARC, MD
Medical Practice in Saint Petersburg, FL

6788394, Sep 7, 2004

Apr 28, 2003

10/249637

Luis Humberto Garcia-Rubio - Temple Terrace FL
Yvette D. Mattley - Tampa FL
German Leparc - Tampa FL
Manuel Bayona - Fort Worth TX
Andres Cardenas - Tampa FL

University of South Florida - Tampa FL

G01N 3348

356 39, 600310, 600314

An infectious disease or disorder in a fluid, such as a mammalian blood sample, is detected by taking a transmission spectrum of a test sample in at least a portion of the ultraviolet visible near-infrared and comparing the spectrum with a standard sample spectrum. From the comparison it is then determined whether the fluid from the test sample contains an infectious disease or disorder, and an identity of the infectious disease or disorder is determined. Spectroscopic and multiwavelength turbidimetry techniques provide a rapid, inexpensive, and convenient means for diagnosis. The comparison and determination steps may be performed visually or by spectral deconvolution.

5589932, Dec 31, 1996

Feb 8, 1995

8/385717

Luis H. Garcia-Rubio - Temple Terrace FL
Manuel Bayona - Lutz FL
Robert Potter - Tampa FL
German Leparc - Tampa FL

University of South Florida - Tampa FL

G01N 3348, A61B 500, G06F 1500

356 39

A method and apparatus for determining the type of a blood sample are provided wherein a turbidity spectrum of the blood sample is collected over a predetermined wavelength range, from which is calculated an extinction spectrum. This extinction spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. A further method is provided for for detecting the presence of a substance in a bodily fluid sample, the substance having a size in the range of generally 0. 5 to 20. mu. m. Exemplary substances that could be of interest to detect include, but are not limited to, hemoglobin, bilirubin, red blood cell antigens, microorganisms, and viruses. This embodiment includes the additional step of deconvoluting the extinction spectrum to obtain a particle size distribution for comparison with a database of control samples.

6330058, Dec 11, 2001

Apr 13, 2000

9/548569

Luis Humberto Garcia-Rubio - Temple Terrace FL
Smita Narayanan - Tampa FL
German Leparc - Tampa FL
Robert Potter - Tampa FL
Sharyn Orton - Rockville MD

University of South Florida - Tampa FL

G01N 3348, G01N 3353

356 39

A method and apparatus for characterizing the type of a blood sample are provided wherein an optical density spectrum of the sample is collected over a predetermined wavelength range. A reference optical density spectrum is collected over a predetermined wavelength range for a portion of the blood sample diluted in saline. Another portion of the blood sample is then mixed with an antibody corresponding to a known blood type (e. g. , anti-A, anti-B, anti-D antibody). The optical density spectrum is then collected over a predetermined wavelength range for blood diluted with saline and each antibody in saline. The slopes are then calculated over a predetermined wavelength range for each spectrum. A numerical indicator of agglutination is then calculated by dividing the slope of each antibody-treated sample by the slope of the sample in saline. The resulting number is multiplied by 100.

2002012, Sep 5, 2002

Jul 12, 2001

09/904107

Luis Garcia-Rubio - Temple Terrace FL, US
Yvette Mattley - Tampa FL, US
German Leparc - Tampa FL, US
Manuel Bayona - Fort Worth TX, US
Andres Cardenas - Tampa FL, US

G01N033/48

356/039000

An infectious disease or disorder in a fluid, such as a mammalian blood sample, is detected by taking a transmission spectrum of a test sample in at least a portion of the ultraviolet-visible-near-infrared and comparing the spectrum with a standard sample spectrum. From the comparison it is then determined whether the fluid from the test sample contains an infectious disease or disorder, and an identity of the infectious disease or disorder is determined. Spectroscopic and multiwavelength turbidimetry techniques provide a rapid, inexpensive, and convenient means for diagnosis. The comparison and determination steps may be performed visually or by spectral deconvolution.

7691642, Apr 6, 2010

Nov 23, 2005

11/164466

Luis Humberto Garcia-Rubio - Temple Terrace FL, US
Robert Potter - Tampa FL, US
German Leparc - Tampa FL, US
Sharyn Orton - Frederick MD, US
Yvette Mattley - Tampa FL, US
Christina Bacon - Tampa FL, US

University of South Florida - Tampa FL

G01N 33/48

436163, 436 1, 436 2, 436 44, 436 46, 436 50, 436 55, 436 61, 436164, 436166, 436171, 435 2, 435 4, 435374, 4352841, 4352871, 422 58

A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined wavelength range. For blood typing, this spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. Further methods and apparatus are provided for determining the viability of and for cross matching a platelet unit Additional method and apparatus permit analysis of the sample for the presence of a contaminant, Particles can also be counted in the sample, even when present in low concentrations, including white blood cell.

7027134, Apr 11, 2006

Sep 3, 2004

10/934601

Luis H. Garcia-Rubio - Temple Terrace FL, US
Catalina E. Alupoaei - Hillsboro OR, US
Willard Harris - Lutz FL, US
Alfredo Peguero - Tampa FL, US
Edward P. Cutolo - Tampa FL, US
German Felix Leparc - Tampa FL, US

University of South Florida - Tampa FL

G01N 33/48

356 39, 600310, 600314

The present invention provides a method and apparatus for the detection of an infectious disease or disorder in a fluid, such as a mammalian blood sample, the detection of a specific protein in a urine sample, or the detection of a particle in a plasma. The identification of the particles of interest is enable by taking a transmission spectrum of a test sample in at least a portion of the ultraviolet, visible, near-infrared portion of the spectrum and comparing the spectrum with a standard sample spectrum. From the comparison it is then determined whether the fluid from the test sample contains an particle of interest, and an identity of the particle of interest is determined. Spectroscopic and multiwavelength turbidimetry techniques provide a rapid, inexpensive, and convenient means for diagnosis. The comparison and determination steps may be performed visually or by spectral deconvolution.