Inventors:
Kathleen E. Rodgers - Long Beach CA
Gere S. DiZerega - Los Angeles CA
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 3808
US Classification:
514 16, 514 17, 424 91, 530316, 530328, 530329, 435325, 435375
Abstract:
The present invention provides improved methods, kits, and pharmaccutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood following chemotherapy, comprising administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues. AII fragments or analogues thereof or AII AT type 2 receptor agonists to a patient in need of chemotherapy.