GERARDO P CARINO, MD
Osteopathic Medicine at Summit Ave, Providence, RI

6677313, Jan 13, 2004

Oct 3, 2000

09/678764

Edith Mathiowitz - Brookline MA
Yong S. Jong - Warwick RI
Gerardo Carino - Providence RI
Jules S. Jacob - Taunton MA

Brown University Research Foundation - Providence RI

A61K 4800

514 44, 4353201, 435455, 424486, 424497

The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.

6156348, Dec 5, 2000

Aug 17, 1998

9/135248

Camila A. Santos - Newport RI
Jules S. Jacob - Taunton MA
Benjamin A. Hertzog - Providence RI
Gerardo P. Carino - Providence RI
Edith Mathiowitz - Brookline MA

Brown University Research Foundation - Providence RI

A61K 950, A61K 4730, A61F 202

424501

Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems. The polymers, for example in the form of microspheres, have improved ability to adhere to mucosal membranes, and thus can be used to deliver a drug or diagnostic agent via any of a range of mucosal membrane surfaces including those of the gastrointestinal, respiratory, excretory and reproductive tracts.

2003007, Apr 24, 2003

May 15, 2002

10/146184

Camilla Santos - Newport RI, US
Jules Jacob - Taunton MA, US
Benjamin Hertzog - Houston TX, US
Gerardo Carino - Providence RI, US
Edith Mathiowitz - Brookline MA, US

Brown University Research Foundation

A61K031/74, A61L015/16

424/448000, 424/078310

Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a base polymer are enhanced by incorporating a short chain polymer with one or more free carboxylic groups into the base polymer to enhance the ability of the base polymer to adhere to a tissue surface such as a mucosal membrane. The short chain polymers can be incorporated within a wide range of base polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, short chain polymers can be incorporated within base polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The short chain polymers can either be solubilized and blended with the base polymer before manufacture or else used as a coating with base polymers over existing systems. The base polymers, for example in the form of microspheres, have improved ability to adhere to mucosal membranes, and thus can be used to deliver a drug or diagnostic agent via any of a range of mucosal membrane surfaces including those of the gastrointestinal, respiratory, excretory and reproductive tracts.

2001000, Apr 5, 2001

Dec 4, 2000

09/729529

Camila Santos - Newport RI, US
Jules Jacob - Taunton MA, US
Benjamin Hertzog - Providence RI, US
Gerardo Carino - Providence RI, US
Edith Mathiowitz - Brookline MA, US

A61B008/00, A61K009/16, A61K009/50

424/423000, 424/009520, 424/009600, 424/433000, 424/434000, 424/436000, 424/497000

Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems. The polymers, for example in the form of microspheres, have improved ability to adhere to mucosal membranes, and thus can be used to deliver a drug or diagnostic agent via any of a range of mucosal membrane surfaces including those of the gastrointestinal, respiratory, excretory and reproductive tracts.

5955096, Sep 21, 1999

Jun 25, 1996

8/670326

Camila A. Santos - Newport RI
Jules S. Jacob - Taunton MA
Benjamin A. Hertzog - Providence RI
Gerardo P. Carino - Providence RI
Edith Mathiowitz - Brookline MA

Brown University Research Foundation - Providence RI

C08G 6704, A61K 900, A61F 200

424434

Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems. The polymers, for example in the form of microspheres, have improved ability to adhere to mucosal membranes, and thus can be used to deliver a drug or diagnostic agent via any of a range of mucosal membrane surfaces including those of the gastrointestinal, respiratory, excretory and reproductive tracts.

6248720, Jun 19, 2001

Jul 3, 1996

8/675454

Edith Mathiowitz - Brookline MA
Yong S. Jong - Warwick RI
Gerardo Carino - Providence RI
Jules S. Jacob - Taunton MA

Brown University Research Foundation - Providence RI

A61K 4800, C12N 1511

514 44

The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.