DR. GERARD MITCHELL HOUSEY, M.D.
Medical Practice in Southfield, MI
License number
Michigan 4301071028
Category
Medical Practice
Type
Clinical Pathology/Laboratory Medicine
Address
Address
16800 Mile Rd SUITE 201, Southfield, MI 48076
Phone
(248) 663-7000
(248) 663-7007 (Fax)
(248) 663-7007 (Fax)
Personal information
See more information about GERARD MITCHELL HOUSEY at radaris.comName
Address
Phone
28520 Streamwood Ln, Southfield, MI 48034
2111 Klingensmith Rd, Bloomfield Hills, MI 48302
28520 Streamwood Ln, Southfield, MI 48034
Professional information
Gerard Mitchell Housey, Southfield MI
Specialties:
Pathologist
Address:
16800 W 12 Mile Rd, Southfield, MI 48076
Compounds And Methods Of Identifying, Synthesizing, Optimizing And Profiling Protein Modulators
US Patent:
2009027, Nov 5, 2009
Filed:
Nov 24, 2006
Appl. No.:
12/085484
Inventors:
Gerard M. Housey - Southfield MI, US
International Classification:
C12Q 1/02
US Classification:
435 29
Abstract:
This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost, reductions in the drug discovery process resulting from the corresponding increases in efficiency.
Compounds And Method Of Identifying, Synthesizing, Optimizing And Profiling Protein Modulators
US Patent:
8431110, Apr 30, 2013
Filed:
Nov 24, 2006
Appl. No.:
11/604109
Inventors:
Gerard M. Housey - Southfield MI, US
Assignee:
HMI Medical Innovations, LLC. - Southfield MI
International Classification:
A61K 49/00, A01N 63/00
US Classification:
424 92, 424 931
Abstract:
This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost reductions in the drug discovery process resulting from the corresponding increases in efficiency.
Theramutein Modulators
US Patent:
2013015, Jun 13, 2013
Filed:
Feb 4, 2013
Appl. No.:
13/758422
Inventors:
Gerard M. Housey - Southfield MI, US
Assignee:
HMI MEDICAL INNOVATIONS, LLC. - Southfiled MI
International Classification:
C07D 239/48, C07D 215/38, C07D 239/42, C07D 253/075, C07D 403/12, C07D 405/12, G01N 33/573, C07D 213/77, C07D 239/84, C07C 243/38, C07D 213/86, C07D 231/14, C07D 215/50, C07D 409/12, C07D 401/12
US Classification:
5142322, 5142358, 544122, 51425214, 514275, 514313, 544332, 544182, 514242, 5142345, 435 78, 506 9, 5142355, 5142664, 544331, 514615, 546325, 514354, 5483741, 514406, 546262, 514332, 514311, 514336
Abstract:
This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.
Method Of Screening Activators And/Or Inhibitors Of Insulin Receptor Substrate 2
US Patent:
8557512, Oct 15, 2013
Filed:
Dec 31, 2003
Appl. No.:
10/541263
Inventors:
Gerard M. Housey - Southfield MI, US
Morris F. White - Norwood MA, US
Morris F. White - Norwood MA, US
Assignee:
HMI Medical Innovations, LLC - Southfield MI
International Classification:
C12Q 1/00, C12N 5/00, C12N 5/07, C12N 15/64, C12N 15/87
US Classification:
435 4, 435 78, 435336, 435 914, 435462, 435463, 435477
Abstract:
This invention is directed to a general method for the chronic treatment, potential cure, or prevention of various metabolic and related diseases in people, including diabetes, by modulating IRS2 activity in cells and tissues in the body. IRS1 and IRS2 are part of the insulin or insulin-like growth factor signaling pathway. By upregulating the levels or functional activity of IRS2, insulin is used more efficiently by the body to control nutrient levels. By upregulating IRS2 levels or functional activity in pancreatic β-cells, glucose sensing and insulin secretion are enhanced.
Therameutin Modulators
US Patent:
8367038, Feb 5, 2013
Filed:
May 23, 2005
Appl. No.:
10/569315
Inventors:
Gerard M. Housey - Southfield MI, US
Assignee:
HMI Medical Innovations, LLC - Southfield MI
International Classification:
A61K 49/00
US Classification:
424 91, 424 931
Abstract:
This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest arc inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.