Inventors:
Andrew S. Janoff - Lawrenceville NJ
Marc J. Ostro - North Brunswick NJ
Alan L. Weiner - Plainsboro NJ
Gerald Weissmann - New York NY
James R. Seibold - Piscataway NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
G01N 33564, B32B 516, B32B 902, B32B 904, A01N 2500, A61K 942
Abstract:
An assay for detecting SLE antibodies utilizing a novel liposome composition in which there is entrapped a divalent cation responsive indicator. The presence of such antibodies is detected by their stabilization of the supermolecular structure of the liposomes. Such stabilization can be detected, and in certain cases, caused by, the addition of magnesium or calcium ions.