GERALD T NEPOM, MD
Medical Practice at 9 Ave, Seattle, WA
License number
Washington MD00019886
Category
Medical Practice
Type
Clinical Biochemical Genetics
Address
Address
1201 9Th Ave, Seattle, WA 98101
Phone
(206) 223-8812
(206) 583-6025
(206) 515-5886 (Fax)
(206) 583-6025
(206) 515-5886 (Fax)
Personal information
See more information about GERALD T NEPOM at radaris.comName
Address
Phone
98 Union St APT 512, Seattle, WA 98101
5388 Crystal Springs Dr, Bainbridge Island, WA 98110
5388 Crystal Springs, Lopez Island, WA 98110
98 Union St, Seattle, WA 98101
5388 Crystal Springs Dr, Bainbridge Is, WA 98110
Professional information
Methods For Identifying The Dqw3.2 Allele Associated With Increased Risk Of Insulin-Dependent Diabetes Mellitus
US Patent:
5196308, Mar 23, 1993
Filed:
Mar 13, 1989
Appl. No.:
7/325058
Inventors:
Gerald T. Nepom - Bainbridge Island WA
Barbara S. Nepom - Bainbridge Island WA
Barbara S. Nepom - Bainbridge Island WA
Assignee:
Genetic Systems Corporation - Redmond WA
International Classification:
G01N 33543, G01N 33564, G01N 33577
US Classification:
435 721
Abstract:
Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3. 2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a labeled probe to detect the DQw3. 2 allele. This method involves estimating the size of the hybridizable DNA fragment generated by a specific restriction endonuclease and therefrom determining the presence of the allele. A second preferred method involves the serologic detection of the DQw3. 2 allele. Within this method, immunocomplexes formed between two different MAb's and separate portions of a cell collection are detected and the presence or absence of the allele determined.
Peptides And Peptide Analogues Designed From A Diabetes-Associated Autoantigen, And Methods For Their Use In The Treatment And Prevention Of Diabetes
US Patent:
2003017, Sep 18, 2003
Filed:
Mar 28, 2003
Appl. No.:
10/403980
Inventors:
Gerald Nepom - Bainbridge Island WA, US
Susan Masewicz - Seattle WA, US
Barbara Nepom - Bainbridge Island WA, US
Susan Masewicz - Seattle WA, US
Barbara Nepom - Bainbridge Island WA, US
International Classification:
A61K038/10, C07K007/06, C07K007/08
US Classification:
514/013000, 530/326000
Abstract:
The present invention relates to peptides and peptide analogues designed from a human pancreatic islet beta cell autoantigen GAD65. In particular, it relates to antagonistic peptides and peptide analogues that antagonize autoimmune T cell activation in response to GAD65. The invention also relates to methods of using such peptides and peptide analogues for the treatment and prevention of type I diabetes or pre-diabetes.
Diagnostic Probe For Rheumatoid Arthritis Predisposition
US Patent:
4971902, Nov 20, 1990
Filed:
Oct 30, 1987
Appl. No.:
7/115253
Inventors:
Gerald T. Nepom - Bainbridge Island WA
Assignee:
Virginia Mason Research Center - Seattle WA
International Classification:
C01N 3300, C12Q 168, C07H 1906, C07H 1512
US Classification:
435 6
Abstract:
Oligonucleotide probes for diagnosing predisposition to rheumatoid arthritis, capable of specifically hybridizing with
5'-TACGGGGTTGR. sub. 1 GAGAGCTT-3'
or
3'-AR. sub. 2 GCCCCAACR. sub. 3 CR. sub. 2 CR. sub. 2 CGAA-5'
wherein A is adenine, C is cytosine, G is guanine, T is thymine, R. sub. 1 is GT or TG, R. sub. 2 is T or uracil, and R. sub. 3 is CA or AC. Or, capable of specifically hybridizing with
5'-GGAGCAGAR. sub. 2 GCGGGCCGCGG-3'
or
3'-CCR. sub. 2 CGR. sub. 2 CR. sub. 2 R. sub. 3 CGCCCGGCGCC-5'
wherein R. sub. 1 is A or G, R. sub. 2 is T or uracil, and R. sub. 3 is R. sub. 2 or C.