GERALD T NEPOM, MD
Medical Practice at 9 Ave, Seattle, WA

License number

Washington MD00019886

Personal information

See more information about GERALD T NEPOM at radaris.com

Name

Address

Phone

Gerald Nepom, age 73

98 Union St APT 512, Seattle, WA 98101

Gerald L Nepom

5388 Crystal Springs Dr, Bainbridge Island, WA 98110

(360) 468-3284
(206) 842-0283

Gerald Nepom

5388 Crystal Springs, Lopez Island, WA 98110

(360) 468-3284

Gerald T Nepom

98 Union St, Seattle, WA 98101

Gerald T Nepom, age 74

5388 Crystal Springs Dr, Bainbridge Is, WA 98110

(206) 842-0283
(360) 468-3284

Professional information

See more information about GERALD T NEPOM at trustoria.com

Methods For Identifying The Dqw3.2 Allele Associated With Increased Risk Of Insulin-Dependent Diabetes Mellitus

US Patent:

5196308, Mar 23, 1993

Filed:

Mar 13, 1989

Appl. No.:

7/325058

Inventors:

Gerald T. Nepom - Bainbridge Island WA
Barbara S. Nepom - Bainbridge Island WA

Assignee:

Genetic Systems Corporation - Redmond WA

International Classification:

G01N 33543, G01N 33564, G01N 33577

US Classification:

435 721

Abstract:

Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3. 2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a labeled probe to detect the DQw3. 2 allele. This method involves estimating the size of the hybridizable DNA fragment generated by a specific restriction endonuclease and therefrom determining the presence of the allele. A second preferred method involves the serologic detection of the DQw3. 2 allele. Within this method, immunocomplexes formed between two different MAb's and separate portions of a cell collection are detected and the presence or absence of the allele determined.

Peptides And Peptide Analogues Designed From A Diabetes-Associated Autoantigen, And Methods For Their Use In The Treatment And Prevention Of Diabetes

US Patent:

2003017, Sep 18, 2003

Filed:

Mar 28, 2003

Appl. No.:

10/403980

Inventors:

Gerald Nepom - Bainbridge Island WA, US
Susan Masewicz - Seattle WA, US
Barbara Nepom - Bainbridge Island WA, US

International Classification:

A61K038/10, C07K007/06, C07K007/08

US Classification:

514/013000, 530/326000

Abstract:

The present invention relates to peptides and peptide analogues designed from a human pancreatic islet beta cell autoantigen GAD65. In particular, it relates to antagonistic peptides and peptide analogues that antagonize autoimmune T cell activation in response to GAD65. The invention also relates to methods of using such peptides and peptide analogues for the treatment and prevention of type I diabetes or pre-diabetes.

Diagnostic Probe For Rheumatoid Arthritis Predisposition

US Patent:

4971902, Nov 20, 1990

Filed:

Oct 30, 1987

Appl. No.:

7/115253

Inventors:

Gerald T. Nepom - Bainbridge Island WA

Assignee:

Virginia Mason Research Center - Seattle WA

International Classification:

C01N 3300, C12Q 168, C07H 1906, C07H 1512

US Classification:

435 6

Abstract:

Oligonucleotide probes for diagnosing predisposition to rheumatoid arthritis, capable of specifically hybridizing with 5'-TACGGGGTTGR. sub. 1 GAGAGCTT-3' or 3'-AR. sub. 2 GCCCCAACR. sub. 3 CR. sub. 2 CR. sub. 2 CGAA-5' wherein A is adenine, C is cytosine, G is guanine, T is thymine, R. sub. 1 is GT or TG, R. sub. 2 is T or uracil, and R. sub. 3 is CA or AC. Or, capable of specifically hybridizing with 5'-GGAGCAGAR. sub. 2 GCGGGCCGCGG-3' or 3'-CCR. sub. 2 CGR. sub. 2 CR. sub. 2 R. sub. 3 CGCCCGGCGCC-5' wherein R. sub. 1 is A or G, R. sub. 2 is T or uracil, and R. sub. 3 is R. sub. 2 or C.