Inventors:
Yong Moon CHOI - Pine Brook NJ, US
Robert Gordon - Robbinsville NJ, US
Gerald P. Novak - Skillman NJ, US
Carlos R. Plata-Salaman - Zionsville IN, US
Roy E. Twyman - Doylestown PA, US
H. Steve White - Salt Lake City UT, US
Boyu Zhao - Lansdale PA, US
International Classification:
A61K 31/27, A61P 25/08
Abstract:
This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof:wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R, R, R, R, Rand Rare independently selected from the group consisting of hydrogen and C-Calkyl; wherein C-Calkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C-Calkyl, C-Calkoxy, amino, nitro and cyano).