Inventors:
Randy W. Scott - Cupertino CA
Gerald J. Gleich - Rochester MN
Craig G. Wilde - Foster City CA
Assignee:
Incyte Pharnaceuticals, Inc. - Palo Alto CA
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
C12P 2106, C12N 120, C07H 2104
Abstract:
Several natural polypeptides (basophil granule proteins, "BGP") derived from the cytoplasmic granules of human basophils, and modified forms thereof, are described. These polypeptides, the DNA which encodes them and antibodies which recognize them, are useful as diagnostics for, and treatments for, pathologies involving inflammatory and IgE-mediated responses, parasitic and helminthic infections, hypersensitivity reactions and certain types of leukocytic leukemias.