GEORGE W ROZAKIS, MD
Medical Practice at Center Ridge Rd, Cleveland, OH

5843070, Dec 1, 1998

May 13, 1996

8/645100

James L. Cambier - Rome NY
George W. Rozakis - Lakewood OH

ParTech, Inc. - New Hartford NY

A61M 506

606 5

An apparatus and method are provided for simulating a predicted post-operative topography of a cornea of an eye based on a pre-operative topography of the cornea and a proposed laser ablation procedure. A digital data processing system receives data defining a pre-operative topography of the cornea as a function of location and obtains parameters of the proposed laser ablation procedure from which the digital data processing system can determine the amount of cornea expected to be ablated as a function of location on the cornea. Based on the data and the parameters, the digital data processing system produces an output representing a simulated post-operative topography of the cornea as a function of location. The parameters of the proposed laser ablation procedure specify variations in a cut rate of the laser beam (such as data specifying a plurality of laser beam cut rates for each of a corresponding plurality of laser beam pulses, or data specifying relative laser beam energy level or fluence at each of a plurality of points within the laser beam).

2007016, Jul 12, 2007

Dec 11, 2006

11/637475

George Rozakis - Lakewood OH, US
Igor Valyunin - Milwaukee WI, US

A61F 2/16

623006440, 623006490

A phakic intraocular lens includes a body having a flat anterior-facing surface and a curved posterior-facing surface that defines the optical power of the lens. The lens allows fluid to flow between the phakic lens and the iris and between the phakic lens and the natural lens. An enlarged outer rim helps maintain the position of the lens. Some embodiments are provided with openings, channels, or both at the circumferential edge of the flat anterior-facing surface or the lens body to help prevent the flat surface of the lens from sealing against the iris.

2004020, Oct 14, 2004

Apr 27, 2004

10/833221

George Rozakis - Lakewood OH, US
Guillermo Avalos - Guadalajara, MX

A61B018/20

606/005000

A system for correcting presbyopia provides a laser adapted to sculpt the cornea in two concentric zones. The first larger zone is treated with a positive diopter correction to allow eye to focus on near objects. A second smaller zone is then treated with a negative diopter correction to allow the cornea to focus on far objects. In one embodiment, the system directs the laser in a series of collapsing crescents to sculpt the zones.

2004018, Sep 16, 2004

Oct 10, 2003

10/683315

Miklos Gratzl - Mayfield Heights OH, US
Koji Tohda - Mayfield Heights OH, US
Jian Yang - Mayfield Heights OH, US
George Rozakis - Lakewood OH, US

C12Q001/54, C12M001/34

435/014000, 435/287100

In vivo or in vitro monitoring of chemical and biochemical species (e.g., pH, or glucose levels) in the interstitial fluid of patients or in a sample of a fluid to be analyzed is provided by a probe (). For in vivo monitoring, the probe is readily inserted by a minimally invasive method. Optical or electrochemical sensing methods are employed to detect a physical or chemical change, such as pH, color, electrical potential, electric current, or the like, which is indicative of the concentration of the species or chemical property to be detected. Visual observation by the patient may be sufficient to monitor certain biochemicals (e.g., glucose) with this approach. A CAP membrane allows high enzyme loadings, and thus enables use of microminiature probes, and/or diagnosis of low levels of the analyte(s), with sufficient signal-to-noise ratio and low background current.

2001003, Oct 18, 2001

Dec 29, 2000

09/752273

George Rozakis - Lakewood OH, US
Guillermo Avalos - Guadalajara JAL, MX

A61B018/20

606/005000

A system for correcting presbyopia provides a laser adapted to sculpt the cornea in two concentric zones. The first larger zone is treated with a positive diopter correction to allow eye to focus on near objects. A second smaller zone is then treated with a negative diopter correction to allow the cornea to focus on far objects. In one embodiment, the system directs the laser in a series of collapsing crescents to sculpt the zones.

7964390, Jun 21, 2011

Feb 3, 2005

11/050584

George Rozakis - Lakewood OH, US
Miklos Gratzl - Mayfield Heights OH, US
Jian Yang - Mayfield Heights OH, US

Case Western Reserve University - Cleveland OH

C12M 1/34, C12M 3/00, G01N 21/76

4352887, 4352872, 4352879, 4352884, 435808, 436172, 422 8205, 422 8206, 422 8207, 600347

A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detectable change when the probe is exposed to the analyte in the fluid. The sensing system may include an enzyme capable of catalyzing a reaction of the analyte to form a reaction product and a dye system which absorbs in the infrared region of the spectrum in response to the reaction product.

2012020, Aug 9, 2012

May 20, 2011

13/112018

George Rozakis - Lakewood OH, US
Miklos Gratzl - Mayfield Heights OH, US
Koji Tohda - Mayfield Heights OH, US
Jian Yang - Hangzhou, CN

A61K 49/00, G01N 21/75

424 91, 436 95

A method of detecting an analyte in a fluid includes the step of positioning a sensor probe in the fluid. The sensor probe includes a sensing element which absorbs in the infrared region of the spectrum in response to the analyte. The change is then detected with a detection system.