Inventors:
Alessia Fornoni - Coral Gables FL, US
George William Burke - Miami FL, US
International Classification:
G01N 33/50, A61K 39/395, A61K 38/17, C12Q 1/68, A61K 31/724
US Classification:
4241341, 435 29, 435 613, 506 10, 506 15, 4352871, 514 58, 4241331
Abstract:
Assays, methods and kits for predicting a subject's (e.g., human) risk of primary glomerulopathy, secondary glomerulopathy or recurrence (e.g., post-transplant recurrence) of any glomerular disease include examining cells for the presence or absence of cytoskeletal disruptions or rearrangements and examining cells for modulation of expression and/or activity of markers such as SMPDL-3b. Assays for predicting if a diabetic subject will develop kidney disease or a patient with FSGS will develop recurrent disease after transplant also include examining cells for the presence or absence of cytoskeletal disruptions or rearrangements and examining cells for modulation of expression and/or activity of markers such as SMPDL-3b. Also described herein are compositions and methods for treating and preventing the afore-mentioned disorders.