GEORGE STEFAN GOLDA
Pilots in El Granada, CA

6831994, Dec 14, 2004

Jul 17, 2001

09/908130

John Bridgham - Hillsborough CA
Kevin Corcoran - Fremont CA
George Golda - El Granada CA
Michael C. Pallas - San Bruno CA
Sydney Brenner - La Jolla CA

Lynx Therapeutics, inc. - Hayward CA

G06K 900

382133, 2504612

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

6654505, Nov 25, 2003

Jul 17, 2001

09/907795

John Bridgham - Hillsborough CA
Kevin Corcoran - Fremont CA
George Golda - El Granada CA
Michael C. Pallas - San Bruno CA
Sydney Brenner - La Jolla CA

Lynx Therapeutics, Inc. - Hayward CA

G06F 15316

382278, 382129

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

6406848, Jun 18, 2002

Nov 16, 1999

09/424028

John Bridgham - Hillsborough CA
Kevin Corcoran - Fremont CA
George Golda - El Granada CA
Michael C. Pallas - San Bruno CA
Sydney Brenner - Cambridge, GB

Lynx Therapeutics, Inc. - Hayward CA

C12Q 168

435 6, 4352883, 4352975, 4352991, 536 221

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

6806052, Oct 19, 2004

Apr 18, 2002

10/124884

John Bridgham - Hillsborough CA
Kevin P. Corcoran - Fremont CA
George S. Golda - El Granada CA
Michael C. Pallas - San Bruno CA
Sydney Brenner - La Jolla CA

Lynx Therapeutics, Inc. - Hayward CA

C12Q 168

435 6, 4352883, 4352975, 4352991, 536 221

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

5443791, Aug 22, 1995

Aug 7, 1992

7/927254

G. Richard Cathcart - San Carlos CA
Thomas Brennan-Marquez - Sunnyvale CA
John A. Bridgham - Hillsborough CA
George S. Golda - El Granada CA
Harry A. Guiremand - Half Moon Bay CA
Marianne Hane - Burlingame CA
Louis B. Hoff - Belmont CA
Eric Lachenmeier - Cupertino CA
Melvyn N. Kronick - Palo Alto CA
Douglas H. Keith - Oakland CA
Paul E. Mayrand - Pacifica CA
Michael L. Metzker - San Bruno CA
William J. Mordan - Mountain View CA
Lincoln J. McBride - Belmont CA
John Shigeura - Fremont CA
Norman M. Whiteley - San Carlos CA

Perkin Elmer - Applied Biosystems Division - Foster City CA

G01N 2101, G01N 3508, G01N 110, G01N 2111

422 65

A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.

2013018, Jul 18, 2013

Dec 4, 2012

13/693658

Kevin Corcoran - Livermore CA, US
George Golda - El Granada CA, US
Michael C. Pallas - San Bruno CA, US
Sydney Brenner - Ely, GB

ILLUMINA, INC. - SAN DIEGO CA

C12Q 1/68

506 2

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

8361713, Jan 29, 2013

Oct 12, 2007

11/974239

John Bridgham - Hillsborough CA, US
Kevin Corcoran - Fremont CA, US
George Golda - El Granada CA, US
Michael C. Pallas - San Bruno CA, US
Sydney Brenner - Cambridge, GB

Illumina, Inc. - San Diego CA

C12Q 1/68, C12P 19/34, C12M 1/36, C07H 21/04

435 61, 435 911, 4352831, 4352872, 422 681, 422 8205, 536 231

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

7282370, Oct 16, 2007

Aug 18, 2005

11/207443

John Bridgham - Hillsborough CA, US
Kevin Corcoran - Fremont CA, US
George Golda - El Granada CA, US
Michael C. Pallas - San Bruno CA, US
Sydney Brenner - Cambridge, GB

Solexa, Inc. - Hayward CA

G01N 21/76, G01N 21/00, G01N 37/00

436172, 436164, 436 56

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

6969488, Nov 29, 2005

Jul 17, 2001

09/908131

John Bridgham - Hillsborough CA, US
Kevin Corcoran - Fremont CA, US
George Golda - El Granada CA, US
Sydney Brenner - La Jolla CA, US
Michael C. Pallas - San Bruno CA, US

Solexa, Inc. - Hayward CA

G01N033/48

422 61, 422 99, 422104, 4352872, 4352885, 4352887, 435810

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

2011012, May 26, 2011

Aug 31, 2010

12/873190

Jon HOSHIZAKI - Cupertino CA, US
Joon Mo YANG - Redwoody City CA, US
Maryam SHARIATI - Sunnyvale CA, US
David COX - Foster City CA, US
Kirk HIRANO - Foster City CA, US
John BRIDGHAM - Hillsborough CA, US
Sam WOO - Redwoody City CA, US
George GOLDA - El Granada CA, US

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

G01N 33/50, G01N 30/00

436 94, 422 681, 422 69

Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.