GEORGE Q DALEY, MD
Osteopathic Medicine at Longwood Ave, Boston, MA

License number
Massachusetts 77502
Category
Osteopathic Medicine
Type
Hematology
Address
Address 2
300 Longwood Ave, Boston, MA 02115
50 Young Rd, Cherry Brook, MA 02493
Phone
(617) 919-2013
(617) 730-0222 (Fax)
(781) 642-8728

Personal information

See more information about GEORGE Q DALEY at radaris.com
Name
Address
Phone
George Daley, age 35
67 Tercentennial Dr, Billerica, MA 01821
George Daley
56 Center St APT 1-5, Dennis Port, MA 02639
(508) 694-7033
George Daley
786 Washington St APT B, Haverhill, MA 01832
(978) 621-1247
George Daley, age 63
50 Young Rd, Weston, MA 02493
George Daley
47 Columbus Ave, North Easton, MA 02356
(339) 206-0083

Professional information

George Daley Photo 1

Methods Of Inducing Cancer Cell Death And Tumor Regression

US Patent:
6777415, Aug 17, 2004
Filed:
Oct 5, 2001
Appl. No.:
09/971545
Inventors:
George Q. Daley - Weston MA 02193
International Classification:
A61K 3144
US Classification:
51425214, 51425218, 51425301, 514290, 514908, 514922
Abstract:
Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.


George Daley Photo 2

Single Nucleotide Polymorphisms In Genes

US Patent:
6727063, Apr 27, 2004
Filed:
Sep 7, 2000
Appl. No.:
09/657472
Inventors:
Eric S. Lander - Cambridge MA
Michele Cargill - Gaithersburg MD
James S. Ireland - Gaithersburg MD
Stacey Bolk - West Roxbury MA
George Q. Daley - Weston MA
Jeanette J. McCarthy - San Diego CA
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
C12Q 168
US Classification:
435 6, 435 911, 435 912
Abstract:
The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis. A role for the thrombospondin gene(s) in vascular disease is also disclosed. Use of single nucleotide polymorphisms in the thrombospondin gene(s) for diagnosis, prediction of clinical course and treatment response, development of therapeutics and development of cell-culture-based and animal models for research and treatment are disclosed.


George Daley Photo 3

Coding Sequence Polymorphisms In Vascular Pathology Genes

US Patent:
6692909, Feb 17, 2004
Filed:
Apr 1, 1998
Appl. No.:
09/054272
Inventors:
Eric S. Lander - Cambridge MA
George Q. Daley - Weston MA
Michele Cargill - Cambridge MA
James S. Ireland - Somerville MA
Steven G. Rozen - Somerville MA
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
C12Q 168
US Classification:
435 6, 536 231, 536 235
Abstract:
The invention provides nucleic acid segments of the human genome, particularly necleic acid segments from the coding region of a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.


George Daley Photo 4

Method Of Enhancing Proliferation And/Or Hematopoietic Differentiation Of Stem Cells

US Patent:
2010027, Nov 4, 2010
Filed:
Apr 28, 2010
Appl. No.:
12/768800
Inventors:
Leonard I. Zon - Wellesley MA, US
Alan J. Davidson - West Roxbury MA, US
George Q. Daley - Weston MA, US
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 35/12, C12N 5/10, C12N 5/071, A61P 7/06
US Classification:
424 9321, 435377, 435366, 435375, 424 937
Abstract:
The present invention provides a method for enhancing the proliferation and/or hematopoietic differentiation and/or maintenance of mammalian stem cells. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy. The method of the present invention comprises increasing the intracellular level of a cdx in stem cells, including hematopoietic stem cells, in culture, either by providing an exogenous cdx protein to the cell, or by introduction into the cell of a genetic construct encoding a cdx. The cdx is selected from the cdx family and includes cdx1, cdx2, or cdx4. The cdx may be a wild type protein appropriate for the species from which the cells are derived, or a mutant form of the protein.


George Daley Photo 5

Detection Of Human Somatic Cell Reprogramming

US Patent:
2011025, Oct 20, 2011
Filed:
Sep 22, 2009
Appl. No.:
13/120192
Inventors:
George Q. Daley - Weston MA, US
In-Hyun Park - Milford CT, US
Thorsten M. Schlaeger - Brookline MA, US
Elayne Chan - Auburndale MA, US
Sutheera Ratanasirintrawoot - Cambridge MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
C12Q 1/70, C12Q 1/68, G01N 33/53
US Classification:
435 5, 435 721, 435 71, 435 61
Abstract:
The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS cells during the reprogramming process. The methods/kits can also be performed using real time using live cell imaging. Also described herein are methods for screening candidate reprogramming agents by monitoring the emergence of fully-reprogrammed iPS cells in the presence and absence of such an agent.


George Daley Photo 6

Method To Produce Induced Pluripotent Stem (Ips) Cells From Non-Embryonic Human Cells

US Patent:
2011015, Jun 23, 2011
Filed:
Nov 6, 2008
Appl. No.:
12/741632
Inventors:
In-Hyun Park - Boston MA, US
George Q. Daley - Weston MA, US
Suneet Agarwal - Belmont MA, US
Paul Hubert Lerou - Newton MA, US
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION - BOSTON MA
International Classification:
C12N 5/071, C12Q 1/68, C12N 15/85, C12N 5/10
US Classification:
435 61, 435366, 435455
Abstract:
The invention provides methods for generating induced pluripotent stem (iPS) cells from normal and mutant adult cells, as well as the iPS cells so generated from such methods. In some aspects, iPS cells are generated by ectopically expressing SOX2 and OCT4 nucleic acids in such adult cells. Other nucleic acids such as but not limited to MYC may also be ectopically expressed in such adult cells in the methods described herein.


George Daley Photo 7

Association Of Thrombospondin Polymorphisms With Vascular Disease

US Patent:
2003019, Oct 16, 2003
Filed:
Nov 13, 2001
Appl. No.:
10/007781
Inventors:
Stacey Bolk - Lexington MA, US
George Daley - Weston MA, US
Jeanette McCarthy - San Diego CA, US
International Classification:
C12Q001/68
US Classification:
435/006000
Abstract:
A role for the thrombospondin gene(s), particularly TSP-2, in vascular disease is disclosed. Use of single nucleotide polymorphisms in the thrombospondin gene(s) for diagnosis, prediction of clinical course and treatment response, development of therapeutics and development of cell-culture-based and animal models for research and treatment are disclosed.


George Daley Photo 8

Method Of Enhancing Proliferation And/Or Hematopoietic Differentiation Of Stem Cells

US Patent:
2010020, Aug 19, 2010
Filed:
Jun 21, 2006
Appl. No.:
11/993310
Inventors:
George Q. Daley - Weston MA, US
Yuan Wang - Boston MA, US
Frank Yates - Boston MA, US
Olaia Naveiras - Cambridge MA, US
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
C12N 5/0735, A61K 35/48
US Classification:
424 937, 435377
Abstract:
The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy.


George Daley Photo 9

Expression Vectors And Uses Thereof

US Patent:
2003017, Sep 18, 2003
Filed:
Oct 18, 2001
Appl. No.:
09/982223
Inventors:
George Daley - Weston MA, US
Eugene Koh - Cambridge MA, US
International Classification:
C12N015/861, C12N007/00, C12N005/06
US Classification:
435/456000, 435/325000, 435/320100, 435/235100
Abstract:
The invention includes viral vectors (e.g., retroviral vectors, e.g., replication deficient retroviral vectors), libraries comprising such vectors, retroviral particles produced by such vectors, retroviral packaging cell lines for production of these particles, integrated proviral sequences derived from the retroviral particles, circularized provirus sequences and mammalian cells upon which the provirus has been introduced. The invention also includes methods of using such sequence, vectors, particles and cells.


George Daley Photo 10

Correction Of Genetic Defects

US Patent:
2003022, Dec 11, 2003
Filed:
Mar 7, 2003
Appl. No.:
10/384361
Inventors:
William Rideout - Cambridge MA, US
Konrad Hochedlinger - Cambridge MA, US
Michael Kyba - Cambridge MA, US
Rita Perlingeiro - Cambridge MA, US
George Daley - Weston MA, US
Rudolf Jaenisch - Brookline MA, US
International Classification:
A61K048/00, C12N005/08, C12N015/85
US Classification:
424/093210, 435/455000, 435/366000
Abstract:
A method of correcting of treating a genetic disorder by combining therapeutic cloning and gene therapy.