Inventors:
Scott M. Freeman - New Orleans LA
George N. Abraham - Rochester NY
Craig S. McCune - Huson NY
Frederick L. Moolten - West Newton MA
David Koeplin - Los Angeles CA
Assignee:
University of Rochester - Rochester NY
International Classification:
A61K 4800, C12N 1500, C12N 1563, C12N 500
Abstract:
A method is provided for eliminating cancer cells from a population of cells containing cancer cells and noncancerous cells in vitro or in vivo comprising: (a) providing a mixture of noncancerous cells and cancer cells; (b) contacting the cancer cells with transgenic cancer cells comprising a foreign gene that renders the transgenic cancer cells susceptible to a therapeutic agent; and (c) contacting the transgenic cancer cells with an amount of said therapeutic agent effective to kill both the transgenic cancer cells and the cancer cells.