GEORGE MICHALOPOULOS
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD044208L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15228
Professional information
Professor And Chairman At Univ. Of Pittsburgh School Of Medicine
Position:
Professor and Chairman at Univ. of Pittsburgh School of Medicine
Location:
Greater Pittsburgh Area
Industry:
Medical Practice
Work:
Univ. of Pittsburgh School of Medicine
since Apr 1991
-
Professor and Chairman
Duke University Health System
Jul 1977 - Jun 1991
-
Professor
George K Michalopoulos, Pittsburgh PA
Specialties:
Pathologist
Address:
200 Lothrop St, Pittsburgh, PA 15213
Education:
University of Athens, School of Health Sciences - Doctor of Medicine
University of Wisconsin Hospital & Clinics - Residency - Pathology
University of Wisconsin Hospital & Clinics - Residency - Pathology
Board certifications:
American Board of Pathology Certification in Anatomic Pathology (Pathology)
Dr. George K Michalopoulos, Pittsburgh PA - MD (Doctor of Medicine)
Specialties:
Anatomic Pathology
Address:
UPMC Presbyterian Pathology
200 Lothrop St, Pittsburgh 15213
(412) 647-2345 (Phone)
200 Lothrop St, Pittsburgh 15213
(412) 647-2345 (Phone)
Certifications:
Anatomic Pathology, 1977
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
UPMC Presbyterian Pathology
200 Lothrop St, Pittsburgh 15213
UPMC Passavant - McCandless
9100 Babcock Blvd, Pittsburgh 15237
Upmc Presbyterian Shadyside
200 Lothrop St, Pittsburgh 15213
Upmc Shadyside
5230 Center Ave, Pittsburgh 15232
200 Lothrop St, Pittsburgh 15213
UPMC Passavant - McCandless
9100 Babcock Blvd, Pittsburgh 15237
Upmc Presbyterian Shadyside
200 Lothrop St, Pittsburgh 15213
Upmc Shadyside
5230 Center Ave, Pittsburgh 15232
Education:
Medical School
University Of Athens, School Of Health Sciences
Graduated: 1969
Wisconsin Hosps
Graduated: 1972
Graduated: 1977
University Of Athens, School Of Health Sciences
Graduated: 1969
Wisconsin Hosps
Graduated: 1972
Graduated: 1977
George Michalopoulos, Pittsburgh PA
Work:
UPMC Presbyterian
200 Lothrop St, Pittsburgh, PA 15213
200 Lothrop St, Pittsburgh, PA 15213
Methods Of Treating Disorders Associated With Protein Polymerization
US Patent:
2012012, May 24, 2012
Filed:
Jan 31, 2012
Appl. No.:
13/362606
Inventors:
David Hirsch Perlmutter - Pittsburgh PA, US
George Konstantine Michalopoulos - Pittsburgh PA, US
Tunde Hidvegi - Gibsonia PA, US
George Konstantine Michalopoulos - Pittsburgh PA, US
Tunde Hidvegi - Gibsonia PA, US
International Classification:
A61K 31/55, A61P 25/16, A61P 25/28
US Classification:
514217
Abstract:
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine, oxcarbazepine or another carbamazepine-like compound. It is based, at least in part, on the discovery that, in cells having a genetic defect in α1-antitrypsin, carbamazepine was able to decrease levels of the mutant protein. Furthermore, carbamazepine reduced the hepatic load of mutant α1-antitrypsin and the toxic effect of that mutant protein accumulation, hepatic fibrosis, in vivo using a mouse model of the disease. As patients having this defect in α1-antitrypsin exhibit toxic accumulations of the protein, treatment according to the invention may be used to ameliorate symptoms and signs of disease.