GEORGE H CROTTS
Pharmacy in Kintnersville, PA
License number
Pennsylvania RP037344L
Category
Pharmacy
Type
Pharmacist
Address
Address
Kintnersville, PA 18930
Personal information
See more information about GEORGE H CROTTS at radaris.comName
Address
Phone
184 Ealer Hill Rd, Kintnersville, PA 18930
3145 Davisville Rd, Hatboro, PA 19040
2815 Byberry Rd, Hatboro, PA 19040
2418 Gallows Hill Rd, Kintnersville, PA 18930
2815 Byberry Rd, Hatboro, PA 19040
Professional information
Compaction Process For Manufacture Of Sodium Phenytoin Dosage Form
US Patent:
2003008, May 1, 2003
Filed:
May 14, 2002
Appl. No.:
10/145063
Inventors:
George Crotts - Kintnersville PA, US
Mebrahtu Fessehaie - Mineola NY, US
Srinivas Gadiraju - Randolph NJ, US
John Gawel - Clark NJ, US
Isaac Ghebre-Sellassie - Morris Plains NJ, US
Ashlesh Sheth - Randolph NJ, US
Mebrahtu Fessehaie - Mineola NY, US
Srinivas Gadiraju - Randolph NJ, US
John Gawel - Clark NJ, US
Isaac Ghebre-Sellassie - Morris Plains NJ, US
Ashlesh Sheth - Randolph NJ, US
International Classification:
A61K009/20, B27N003/00, A61K031/4166
US Classification:
514/389000, 264/109000, 424/465000
Abstract:
A process for the roller compaction and manufacture of a pharmaceutical formulation comprises the steps of adding sodium phenytoin to a vessel of a blender and adding at least one excipient to the vessel. The mixture is blended and transferred to a roller compactor, where pressure is applied to the blend of sodium phenytoin and excipient. Next, the resultant compaction is milled to form a granulation, which is blended a second time and is suitable for further processing into a dosage form. Preferably, the excipients include magnesium stearate, sugar, lactose monohydrate, and talc. In an alternative embodiment, talc is added immediately prior to the granulation being blended for a second time.