GEORGE F MUSCHLER, MD
Medical Practice at Euclid Ave, Cleveland, OH

6049026, Apr 11, 2000

May 21, 1998

9/082984

George Frederick Muschler - Cleveland Heights OH

The Cleveland Clinic Foundation - Cleveland OH

A61F 228, A61K 3940, B01D 1508

623 16

A kit for preparing an implantable graft, particularly an implantable, composite bone graft is provided. The kit includes a porous, biocompatible, sterile substrate and a container configured to retain the substrate and to permit flow of a cell suspension, particularly a bone marrow aspirate suspension therethrough. A method which employs such kit for preparing a composite implantable bone graft is also provided. The method includes the steps of providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. The composite bone graft prepared by the present method contains an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a composite bone marrow graft prepared according to the present method.

5626579, May 6, 1997

Jun 28, 1995

8/495924

George F. Muschler - Cleveland Heights OH
Helmuth Kotschi - Strongsville OH
William A. Smith - Lyndhurst OH

The Cleveland Clinic Foundation - Cleveland OH

A61B 1756

606 60

A surgically implantable cable apparatus has a means for securing (32) a first bone segment (12) and a second bone segment (13). A flexible cable (17) is attached at one end relative to one bone segment (25). A flexible non-compressible sheath (15) has a bore (16) for slidably receiving the cable (17). The non-compressible sheath (15) is secured to the securing means (32) at point (40) and transmits a counter-compression force to the bone segment (25). An implantable actuator (36) is connected to the second end (19) of the flexible cable (17) and to the second end of the sheath (15). The implantable actuator (36) is fully implantable subcutaneously. The implantable actuator (36) is responsive to a transcutaneous energy signal and pulls the flexible cable (17) through the sheath (15) in an axial direction. The cable movement is applied to the bone segment (25), either directly or transmitted through an internal fixation device and the bone segment (25) moves a predetermined distance. Art energy source (42) generates the transcutaneous energy signal which activates the implantable actuator (36) through an intact skin layer (44).

2007005, Mar 8, 2007

Nov 9, 2006

11/595472

George Muschler - Cleveland Heights OH, US

A61F 2/00, A61B 10/00

606092000, 600562000, 600564000

A minimally invasive apparatus and method for harvesting bone marrow cells, blood, and bone fragments includes a rigid cannula having a proximal end and a distal end with an opening. The distal end includes a cutting tip that is movable axially and radially to cut and disrupt bone tissue while preserving necessary viability among harvested marrow cells. The cannula further includes an inner surface defining an internal passage that extends from the opening toward the proximal end. Suction is applied to the passage to draw disrupted bone marrow cells, blood, and bone fragments into the internal passage for collection. The apparatus may include a rotatable shaft disposed co-axially within the internal passage. The shaft has a distal end with a cutting bit for further cutting and disrupting of bone tissue, and a lumen for supplying bone cement to the cutting bit to promote bone growth and healing within the bone.

5824084, Oct 20, 1998

Jul 3, 1996

8/675498

George Frederick Muschler - Cleveland Heights OH

The Cleveland Clinic Foundation - Cleveland OH

A61F 228, A61F 202

623 16

The present invention provides a new and improved method for preparing a composite bone graft. The method includes providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. Because the method is preferably performed intraoperatively it reduces the number of occasions the graftee must undergo invasive procedures. The invention also relates to an improved composite bone graft prepared according to the present method. The improved composite graft includes an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a kit including the apparatus used for preparing the composite bone graft.

2004019, Sep 30, 2004

Mar 31, 2004

10/813986

George Muschler - Cleveland Heights OH, US

The Cleveland Clinic Foundation

C12N005/00

435/325000

A minimally invasive apparatus and method for harvesting bone marrow cells, blood, and bone fragments includes a rigid cannula having a proximal end and a distal end with an opening. The distal end includes a cutting tip that is movable axially and radially to cut and disrupt bone tissue while preserving necessary viability among harvested marrow cells. The cannula further includes an inner surface defining an internal passage that extends from the opening toward the proximal end. Suction is applied to the passage to draw disrupted bone marrow cells, blood, and bone fragments into the internal passage for collection. The apparatus may include a rotatable shaft disposed co-axially within the internal passage. The shaft has a distal end with a cutting bit for further cutting and disrupting of bone tissue.

2006022, Oct 12, 2006

Oct 14, 2005

11/250287

Shuvo Roy - Shaker Heights OH, US
George Muschler - Cleveland Heights OH, US
Aaron Fleischman - University Heights OH, US
Alvaro Mata - Chicago IL, US

A61F 2/02, C12N 5/08

623023740, 435396000

An implant includes a plurality of parallel layers spaced apart by a plurality of members. Each layer has a substantially uniform thickness between opposite surfaces and a plurality of openings that permit fluid flow through an interior of the implant defined by the layers. The surfaces of each layer includes an array of micro-structures. Each micro-structure has a substantially uniform shape and an average height of about 1 nm to about 20 μm.