Inventors:
Richard Mulligan - Cambridge MA, US
George J. Murphy - Boston MA, US
Assignee:
CHILDREN'S HOSPITAL BOSTON - BOSTON MA
International Classification:
A61K 35/12, C12Q 1/68, C12P 21/06, C12N 5/10, C12N 15/63, A61K 31/7088, C07H 21/04
US Classification:
424 937, 435 6, 435 691, 435325, 4353201, 514 44 R, 536 231
Abstract:
In certain embodiments, the disclosure relates to compositions and methods relating to a translation-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to methods of regulating gene expression via modulating translational termination.