Medical School University Of Toronto Faculty Of Medicine Graduated: 1980 Toronto Western Hospital Graduated: 1981 Mass Mntl Health Ctr/Harvard Graduated: 1985 Nimh Graduated: 1990
Rat Or Mouse Exhibiting Behaviors Associated With Human Schizophrenia
US Patent:
5549884, Aug 27, 1996
Filed:
Oct 28, 1992
Appl. No.:
7/967367
Inventors:
Daniel R. Weinberger - Washington DC Barbara K. Lipska - Annandale VA George E. Jaskiw - Lyndhurst OH
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
A61K 4900, C12N 1500, G01N 3700
US Classification:
424 92
Abstract:
This invention provides a unique and surprisingly accurate animal model for human schizophrenia. The animals are brain damaged while prepubescent. The brain damage consists of a ventral hippocampus lesion induced by exposure of the hippocampus region to a neurotoxin. When the animal reaches puberty, abnormal behavior and a number of biological phenomena associated with schizophrenic symptoms emerge. These animals are useful for assaying pharmaceutical compounds for anti-schizophrenic activity.