GEORGE COUKOS
Medical Practice in Penn Wynne, PA
License number
Pennsylvania MD060556L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Penn Wynne, PA 19096
Professional information
Methods And Compositions For Treating Solid Tumors And Enhancing Tumor Vaccines
US Patent:
2009021, Aug 27, 2009
Filed:
Mar 21, 2008
Appl. No.:
12/076759
Inventors:
Ronald J. Buckanovich - Ann Arbor MI, US
George Coukos - Wynnewood PA, US
Andrea Facciabene - Philadelphia PA, US
George Coukos - Wynnewood PA, US
Andrea Facciabene - Philadelphia PA, US
International Classification:
A61K 39/395, A61K 31/506, A61K 31/7105, C12Q 1/68, G01N 33/574, A61P 35/00
US Classification:
4241301, 514256, 435 6, 435 723
Abstract:
The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting the subject with a compound or composition that modulates the expression or activity of ETRB, ET-1, ICAM-1, or another protein found herein to play a role in homing of T cells to a solid tumor. The present invention also provides methods of prognosticating a solid tumor in a subject, comprising the step of measuring an expression level of a protein found herein to play a role in homing of T cells to a solid tumor, or a nucleotide molecule encoding same.
Therapeutic Use Of A Tlr Agonist And Combination Therapy
US Patent:
2012021, Aug 30, 2012
Filed:
Oct 3, 2011
Appl. No.:
13/252147
Inventors:
Robert Hershberg - Seattle WA, US
George Coukos - Wynnewood PA, US
Gregory Dietsch - Snohomish WA, US
Andrea Facciabene - Philadelphia PA, US
Kristi Manjarrez - Seattle WA, US
Tressa D. Randall - Mukilteo WA, US
George Coukos - Wynnewood PA, US
Gregory Dietsch - Snohomish WA, US
Andrea Facciabene - Philadelphia PA, US
Kristi Manjarrez - Seattle WA, US
Tressa D. Randall - Mukilteo WA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
VentiRx Pharmaceuticals, Inc. - Seattle WA
VentiRx Pharmaceuticals, Inc. - Seattle WA
International Classification:
A61K 31/55, A61K 31/7068, A61K 31/664, A61N 5/00, A61K 9/127, A61K 39/395, A61K 38/22, A61K 38/19, A61K 31/704, A61P 35/00
US Classification:
424450, 51421301, 514 34, 514 49, 514110, 4241301, 514 97, 514 76, 600 1
Abstract:
The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
Tumor Vascular Marker-Targeted Vaccines
US Patent:
2012003, Feb 9, 2012
Filed:
Sep 29, 2009
Appl. No.:
13/121638
Inventors:
George Coukos - Wynnewood PA, US
Andrea Facciabene - Philadelphia PA, US
Andrea Facciabene - Philadelphia PA, US
International Classification:
A61M 5/00, A61P 35/00, A61K 51/10, A61P 37/04, A61K 39/00, A61K 39/395
US Classification:
604 20, 4242771, 4241741, 4241931, 42419711, 4241991, 424 149, 4241781
Abstract:
The present invention provides methods of immunizing a subject against a tumor, inhibiting tumor growth, inhibiting tumor recurrence, treating, suppressing the growth of, or decreasing the incidence of a tumor, overcoming tolerance to a tumor vasculature marker (TVM) in a subject comprising the step of administering a vaccine comprising a TVM or a nucleic acid encoding a TVM and related vaccines. The present invention also provides a method of targeting a tumor vasculature in a subject having a tumor comprising the step of contacting said subject with a labeled compound that binds a) a tumor vasculature marker (TVM) or b) a nucleic acid molecule encoding said TVM.
Tumor Vasculature Markers And Methods Of Use Therof
US Patent:
2009027, Nov 5, 2009
Filed:
Jan 25, 2007
Appl. No.:
12/162235
Inventors:
George Coukos - Wynnewood PA, US
Ronald J. Buckanovich - Ann Arbor MI, US
Phyllis A. Gimotty - Philadelphia PA, US
Ronald J. Buckanovich - Ann Arbor MI, US
Phyllis A. Gimotty - Philadelphia PA, US
International Classification:
A61K 51/00, A61K 49/00, A61K 39/395, A61K 31/7105, G01N 33/48, C12Q 1/04, C12Q 1/68, C07K 7/00, C07K 16/30
US Classification:
424 149, 424 91, 4241781, 514 44 A, 436 64, 435 34, 435 6, 530326, 5303879
Abstract:
This invention provides methods of detecting and localizing tumor vasculature cells (TVC) and solid tumors; and treating, impeding vascularization of, and determining the stage of solid tumors in a subject, comprising the step of contacting a subject or a TVC with a ligand that binds to a nucleic acid molecule of the present invention, or binds to a protein encoded by the nucleic acid molecule.
Compositions And Methods For Treating Cancer
US Patent:
2014005, Feb 20, 2014
Filed:
Jan 18, 2012
Appl. No.:
13/979927
Inventors:
Daniel J. Powell - Bala Cynwyd PA, US
George Coukos - Wynnewood PA, US
George Coukos - Wynnewood PA, US
International Classification:
A61K 35/14, C07K 14/705, C07K 16/28
US Classification:
424 9321, 536 231, 5303879, 530350, 536 2353, 435325, 4353201
Abstract:
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
Anti-Tem1 Antibodies And Uses Thereof
US Patent:
2012029, Nov 22, 2012
Filed:
Nov 12, 2010
Appl. No.:
13/508925
Inventors:
Nathalie Scholler - Penn Valley PA, US
Aizhi Zhao - Rose Valley PA, US
Donald Siegel - Lansdale PA, US
George Coukos - Wynnewood PA, US
Aizhi Zhao - Rose Valley PA, US
Donald Siegel - Lansdale PA, US
George Coukos - Wynnewood PA, US
International Classification:
C07K 16/18, A61K 51/10, A61K 39/395, A61P 35/00, C12N 1/16, C12N 15/81, C40B 30/04, C40B 40/02, A61K 39/44, G01N 33/574
US Classification:
424 149, 5303879, 5303873, 4241781, 4241391, 435 723, 4352551, 435471, 506 9, 506 14, 4353201
Abstract:
The invention relates to Anti-TEM 1 anti-bodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.