Inventors:
Kevin D Nelson - Arlington TX, US
Andres A. Romero-Sanchez - Arlington TX, US
George M. Smith - Lexington KY, US
Nadir Alikacem - Allen TX, US
Delia Radulescu - Arlington TX, US
Paula Waggoner - Burleson TX, US
Zhibing Hu - Denton TX, US
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61F002/02, A61K047/30
Abstract:
The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.