George Anthony Luiken
Physician in San Diego, CA

6652836, Nov 25, 2003

Apr 9, 2001

09/832297

George A. Luiken - Coronado CA

FluoroProbe, Inc. - Coronado CA

A61B 1000

424 96, 424 111, 424 149, 424 91, 600317, 600332, 600476

Methods are provided for in vivo detection of diseased tissue in a subject, such as tumor tissue located in a body opening, by administering to the subject a biologically compatible fluorescing targeting construct that binds to or is specifically taken up by the diseased tissue. The observer directly views fluorescence emanating from the fluorescing targeting construct bound to or taken up by the diseased tissue upon irradiation of the targeting construct with excitation light having at least one wavelength in the range from 401 nm to about 495 nm, but preferably lacking light having a wavelength above about 500 nm, so as to determine the location and/or surface area of the diseased tissue in the subject. Since excitation wavelength does not penetrate through tissue, as is the practice in near IR diagnostics, the diseased or abnormal tissue is exposed to the excitation light either surgically or by means of an endoscopic device. Preferably a filter is used to filter out any wavelengths in the excitation light greater than about 500 nm.

2013008, Apr 4, 2013

May 22, 2012

13/477895

George A. Luiken - Coronado CA, US

A61B 5/00, A61B 17/3205

600431, 606167

The present invention describes light source devices to provide white and blue (401-510 nm) light for the in vivo identification of diseased tissue using fluorescence based tissue targeting. The light source devices are configured with a variety of LED lights capable of emitting white and blue light with at least one excitation wavelength in the range from about 401 nm to about 500 nm (for example, 470 nm to 495 nm) to irradiate an in vivo body part of a subject containing tumor or diseased tissue. The tumor or diseased tissue has fluorophore-tagged targeting constructs attached. The fluorophores used in the targeting constructs have emission spectra greater than 515 nm. The fluorescence emanating from the fluorescent targeting construct in response to the excitation wavelength is directly viewed with long-pass filtered (515 nm) lenses and is used to determine the location and/or surface area of the diseased tissue in the subject. Fluorescence based surgical identification provides more accurate disease resection.

2013028, Oct 24, 2013

Apr 17, 2013

13/864766

George A. Luiken - Coronado CA, US

A61B 5/00, A61B 1/04

600431, 600109

Endoscopic devices and methods for imaging and treating organs and tissues are described. The endoscopic devices described herein include flexible endoscopes, rigid endoscopes, and capsule endoscopes. The endoscopic device may comprise one or more cameras and one or more light sources. In some embodiments, the endoscopic device comprises at least one white light camera, at least one blue light camera, at least one white light source, and at least one blue light source. In some embodiments, fluorescent targeting constructs can be injected into the subject and bound to and/or taken up by a tumor or diseased tissue. Diseased tissue can be identified by viewing the fluorescence emanating from the fluorescent targeting constructs by illuminating an in vivo body part of the subject with light having at least one excitation wavelength in the range from 400 nm to about 510 nm.

6299860, Oct 9, 2001

Oct 15, 1998

9/173190

George Luiken - Coronado CA

Fluoro Probe, Inc. - Coronado CA

A61K 4900, G01N 3100, G01N 3348

424 96

Methods are provided for in vivo detection of tissue associated with a disease state in a subject, such as tissue located in a body opening. In the invention method, the subject is administered a biologically compatible fluorescing targeting construct, the construct is allowed to bind to any target tissue present in the subject, a body part of the subject suspected of containing the target tissue is irradiated with UV light while extraneous light to the body part is substantially eliminated, and fluorescence emanating from the fluorescing targeting construct bound to the target tissue is detected and visualized by the observer with or without the aid of an endoscope, so as to determine the location and size of the target tissue. The invention methods offer the advantage that diseased or abnormal tissue can be detected at interior body sites with or without the aid of an endoscopic device. Once the diseased or abnormal tissue has been identified, for example in a surgical opening, such tissue can be readily biopsied or excised surgically.

8463365, Jun 11, 2013

Sep 17, 2008

12/212582

George A. Luiken - San Diego CA, US

OncoFluor, Inc. - Coronado CA

A61B 6/00

600476, 600310, 424 149

The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method includes parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition including an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.

2012019, Jul 26, 2012

Jan 25, 2012

13/358380

George A. Luiken - Coronado CA, US

ONCOFLUOR, INC. - Coronado CA

A61B 1/06, A61B 1/005, A61B 1/00

600139, 600160, 600249

The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species (using the fluorescence of the fluorescing targeting construct) provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection.