GEORGE ALLEN, MD
Medical Practice in Nashville, TN

5230338, Jul 27, 1993

Apr 22, 1992

7/873535

George S. Allen - Nashville TN
Robert L. Galloway - Nashville TN
Robert J. Maciunas - Nashville TN
Charles A. Edwards - Nashville TN
Martin R. Zink - Madison TN

A61B 600

128653

An interactive system for guiding the use of a surgical tool uses at least one imaging technique, such as CT scanning. A mechanical arm has a fixed base at a first end and a tool holder that holds the surgical tool at a second end. A display displays one or more images from the image space of a patient's anatomy. A computer is coupled to the display and the mechanical arm. The computer tracks the location of the surgical tool through physical space, performs a transforming rotation of the physical space to the image space, and causes the display to display the location of the surgical tool within the image space.

5178164, Jan 12, 1993

Mar 29, 1991

7/677096

George S. Allen - Nashville TN

A61B 1900, A61F 232

128898

The present invention pertains to a fiducial implant for the human body that is detectable by an imaging system. The invention is comprised of a first portion and a second portion. The first portion is configured to be detected by an imaging system when placed beneath the skin. The second portion is configured for fixed attachment to a bone beneath the skin without penetrating entirely through the bone and without fracturing the bone. The first portion is sufficiently large and comprised of a material for detection by an imaging system, and sufficiently small to avoid the distortion of the skin when placed at an interface between the skin and the bone. The first portion also has at least a portion which is spherical and defines a surface for cooperating with a tool for securing the second portion to the bone. Additionally, the placement of three fiducial implants into a portion of anatomy of the human body allows for the recreation of a particular image slice of the portion of the anatomy taken by an imaging system with respect to a first time period, at subsequent imaging sessions and also with different scan modalities. This provides a doctor with the ability to accurately follow the progress of the portion of the anatomy of interest.

5211164, May 18, 1993

Mar 29, 1991

7/677088

George S. Allen - Nashville TN

A61B 603

1286531

The present invention pertains to a fiducial implant for the human body that is detectable by an imaging system. The invention is comprised of a first portion and a second portion. The first portion is configured to be detected by an imaging system when placed beneath the skin. The second portion is configured for fixed attachment to a bone beneath the skin without penetrating entirely through the bone and without fracturing the bone. The first portion is sufficiently large and comprised of a material for detection by an imaging system, and sufficiently small to avoid the distortion of the skin when placed at an interface between the skin and the bone. The first portion also has at least a portion which is spherical and defines a surface for cooperating with a tool for securing the second portion to the bone. Additionally, the placement of three fiducial implants into a portion of anatomy of the human body allows for the recreation of a particular image slice of the portion of the anatomy taken by an imaging system with respect to a first time period, at subsequent imaging sessions and also with different scan modalities. This provides a doctor with the ability to accurately follow the progress of the portion of the anatomy of interest.

5097839, Mar 24, 1992

Feb 13, 1990

7/479262

George S. Allen - Nashville TN

A61B 603

1286531

The present invention pertains to a fiducial implant for the human body that is detectable by an imaging system. The invention is comprised of a first portion and a second portion. The first portion is configured to be detected by an imaging system when placed beneath the skin. The second portion is configured for fixed attachment to a bone beneath the skin without penetrating entirely through the bone and without fracturing the bone. The first portion is of detectable size and comprised of a material for detection by an imaging system, and sufficiently small to avoid the distortion of the skin when placed at an interface between the skin and the bone. The first portion also has at least a portion which is spherical and defines a surface for cooperating with a tool for securing the second portion to the bone. Additionally, the placement of n fiducial implants, where n. gtoreq. 4 and is an integer, into a portion of anatomy of the human body allows for the recreation of a particular image slice of the portion of the anatomy taken by an imaging system with respect to a first time period, at subsequent imaging sessions and also with different scan modalities.

5119817, Jun 9, 1992

Jan 19, 1990

7/467243

George S. Allen - Nashville TN

A61B 603

1286531

The present invention pertains to a fiducial implant for the human body that is detectable by an imaging system. The invention is comprised of a first portion and a second portion. The first portion is configured to be detected by an imaging system when palce beneath the skin. The second portion is configured for fixed attachment to a bone beneath the skin without penetrating entirely through the bone and without fracturing the bone. The first portion is sufficiently large and comprised of a material for detection by an imagaging system, and sufficiently small to avoid the distortion of the skin when placed at an interface between the skin and the bone. The first portion also has at least a portion which is spherical and defines a surface for cooperating with a tool for securing the second portion to the bone. Additionally, the placement of three fiducial implants into a portion of anatomy of the human body allows for the recreation of a particular image slice of the portion of the anatomy taken by an imaging system with respect to a first time period, at subsequent imaging sessions and also with different scan modalities. This provides a doctor with the ability to accurately follow the progress of the portion of the anatomy of interest.

5590215, Dec 31, 1996

Apr 21, 1995

8/427634

George S. Allen - Nashville TN

G06K 900

382128

A technique for integrating voxelly-assigned information regarding a portion of anatomy derived from a number of sources into an accurate, single two dimensional pixel-based representation of a view of that anatomy is disclosed. Empirical relationships between known properties are used to infer values for unknown properties.

5142930, Sep 1, 1992

Mar 29, 1991

7/677083

George S. Allen - Nashville TN
Robert L. Galloway - Nashville TN
Robert J. Maciunas - Nashville TN
Charles A. Edwards - Nashville TN
Martin R. Zink - Madison TN

G05G 100, B25J 1700, B25J 1904

74469

An interactive system for guiding the use of a surgical tool uses at least one imaging technique, such as CT scanning. A mechanical arm has a fixed base at a first end and a tool holder that holds the surgical tool at a second end. A display displays one or more images from the image space of a patient's anatomy. A computer is coupled to the display and the mechanical arm. The computer tracks the location of the surgical tool through physical space, performs a transforming rotation of the physical space to the image space, and causes the display to display the location of the surgical tool within the image space.

5298513, Mar 29, 1994

May 29, 1992

7/891485

Rudolf Schohe - Wuppertal, DE
Thomas Glaser - Roesrath, DE
Jorg Traber - Lohmar, DE
George S. Allen - Nashville TN

Bayer Aktiengesellschaft - Leverkusen

A61K 31445, C07D21158

514319

For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2-aminotetralins of the formula ##STR1## in which R. sup. 1 represents hydrogen or alkyl, R. sup. 2 represents hydrogen, alkyl or acyl, and R. sup. 3 represents quinuclidine or a group of the formula --(CH. sub. 2). sub. a --R. sup. 4, --CH. sub. 2 --CH. dbd. CH--(CH. sub. 2). sub. b --R. sup. 4, --CH. sub. 2 --C. tbd. C--(CH. sub. 2). sub. b --R. sup. 4, ##STR2## wherein a denotes a number from 1 to 10, b denotes a number 0, 1, 2, 3 or 4, c denotes a number 0, 1 or 2, d denotes a number 2 or 3, and X denotes oxygen, sulphur or NR. sup. 5, and their salts.

4968679, Nov 6, 1990

May 22, 1989

7/354950

Bodo Junge - Wuppertal, DE
Bernd Richter - Bergisch Gladbach, DE
Thomas Glaser - Roesrath, DE
Jorg Traber - Lohmar, DE
George S. Allen - Nashville TN

Bayer Aktiengesellschaft - Leverkusen

A61K 31135, C07C21138

5142222

New 8-substituted 2-aminotetralins can be prepared from the corresponding aminotetralins or tetralones. They can be used in medicaments.