Inventors:
Geoffrey C. Gurtner - Palo Alto CA, US
Jayakumar Rajadas - Cupertino CA, US
Michael Gabriel Galvez - Palo Alto CA, US
Evgenios Neofytou - Stanford CA, US
International Classification:
A61K 9/70, A61K 31/164, A61K 31/44, A61K 31/4196, A61K 31/195, A61P 17/02
US Classification:
424449, 514616, 514348, 514383, 514423
Abstract:
Compositions and methods are provided for the treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1α in the wound. Agents that increase HIF-1α activity include, without limitation, agents that stabilize HIF-1α, e.g. deferoxamine, deferiprone, deferasirox, etc.; agents that upregulate expression of HIF-1α, e.g. dimethyloxalylglycine, etc., HIF-1α polypeptide or coding sequences; and combinations thereof. Such agents may be referred to herein as HIF-1α potentiating agents.