DR. GENE HENRY BARNETT, M.D.
Medical Practice at Euclid Ave, Cleveland, OH

6377839, Apr 23, 2002

May 29, 1998

09/087370

Iain H. Kalfas - Beachwood OH
Donald W. Kormos - Parma OH
David W. Piraino - Shaker Heights OH
Gene H. Barnett - Shaker Heights OH
Charles P. Steiner - Euclid OH

The Cleveland Clinic Foundation - Cleveland OH

A61B 500

600426, 600427, 600429, 606130, 128897

A patient is secured to a subject support ( ). A stereotaxic wand ( ) is inserted into a tool guide ( ). The wand has a tip portion ( ), a portion extending along a pointing axis ( ) of the wand, an offset portion ( ) which is offset from the pointing axis of the wand, and at least two wand emitters ( ), mounted in alignment with the pointing axis of the wand. The two emitters selectively emit wand signals which are received by three receivers ( ) mounted to a frame assembly ( ). The tool guide includes a bore ( ) extending along a guide axis. The bore is configured for selectively receiving a tool and the tip portion of the wand. An entry point and a trajectory are identified by the surgeon with the wand in the guide. More specifically, a trajectory and location of the wand are superimposed on a diagnostic image on a monitor ( ). If the surgeon is satisfied with the entry point and trajectory shown on the monitor, a surgical tool is inserted into the bore while the tool guide is held along the designated trajectory and at the designated entry point.

5732703, Mar 31, 1998

May 20, 1996

8/650455

Iain H. Kalfas - Beachwood OH
Donald W. Kormos - Parma OH
David W. Piraino - Shaker Heights OH
Gene H. Barnett - Gates Mills OH
Charles P. Steiner - Pepper Pike OH

The Cleveland Clinic Foundation - Cleveland OH

A61B 600

1286531

A patient is secured to a subject support (10). A stereotaxic wand (40) is inserted into a tool guide (60). The wand has a tip portion (44), a portion extending along a pointing axis (46) of the wand, an offset portion (42) which is offset from the pointing axis of the wand, and at least three wand emitters (48, 50, 52), mounted in alignment with the pointing axis of the wand. The three emitters selectively emit infrared light which is received by two CCD cameras (14) mounted to a frame assembly (12). The tool guide includes a bore (76) extending along a guide axis. The bore is configured for selectively receiving a tool and the tip portion of the wand. An entry point and a trajectory are identified by the surgeon with the wand in the guide. More specifically, a trajectory and location of the wand are superimposed on a diagnostic image on a monitor (30). If the surgeon is satisfied with the entry point and trajectory shown on the monitor, a surgical tool is inserted into the bore while the tool guide is held along the designated trajectory and at the designated entry point.

5517990, May 21, 1996

Apr 8, 1994

8/224955

Iain H. Kalfas - Beachwood OH
Donald W. Kormos - Parma OH
David W. Piraino - Shaker Heights OH
Gene H. Barnett - Shaker Heights OH

The Cleveland Clinic Foundation - Cleveland OH

A61B 600

1286531

A patient is secured to a subject support (10). A stereotaxic wand (40) is inserted into a tool guide (60). The wand has a tip portion (44), a portion extending along a pointing axis (46) of the wand, an offset portion (42) which is offset from the pointing axis of the wand, and at least two wand emitters (48, 50), mounted in alignment with the pointing axis of the wand. The two emitters selectively emit wand signals which are received by three receivers (14) mounted to a frame assembly (12). The tool guide includes a bore (66) extending along a guide axis. The bore is configured for selectively receiving a tool and the tip portion of the wand. An entry point and a trajectory are identified by the surgeon with the wand in the guide. More specifically, a trajectory and location of the wand are superimposed on a diagnostic image on a monitor (30). If the surgeon is satisfied with the entry point and trajectory shown on the monitor, a surgical tool is inserted into the bore while the tool guide is held along the designated trajectory and at the designated entry point.

6884591, Apr 26, 2005

Jun 25, 2001

09/891023

Damir Janigro - Cleveland Heights OH, US
Marc Mayberg - Chagrin Falls OH, US
Gene Barnett - Gates Mills OH, US

The Cleveland Clinic Foundation - Cleveland OH

G01N033/53, G01N033/567

435 71, 735 721, 735 794

The present invention relates generally to a peripheral marker or marker of blood brain barrier integrity and methods of using them in the diagnosis, prognosis, and treatment of a variety of diseases. The preferred embodiments of the present invention relate to methods, compositions, kits, and assays useful in determining the integrity or permeability of a blood brain barrier. The various embodiments of the present invention can be used to identify subjects at risk for developing a disease associated with increased permeability of the blood brain barrier, as well as to provide insight on the ability of an agent or agents to pass the blood brain barrier. Preferably, increased levels of S100β protein are used alone or in combination with other markers of diseased state in order to diagnose and prognosticate permeability of the BBB.

5904691, May 18, 1999

Sep 26, 1997

8/938299

Gene H. Barnett - Gates Mills OH
Christopher H. Wood - Bellevue WA
Patrick A. Dayton - Monroe Falls OH

Picker International, Inc. - Cleveland OH
The Cleveland Clinic Foundation - Cleveland OH

A61B19/00

606130

A surgical guide for use with an image guided surgery includes first and second surfaces. At least three signaling devices such as infrared emitters are disposed on the first surface, and a cylindrical mounting boss is disposed on the second surface. A guide aperture is perpendicular to the first and second surfaces and extends between them. The guide aperture is configured to support a surgical tool such as a biopsy needle. A sleeve may be placed in the aperture to support additional tools.

5967982, Oct 19, 1999

Dec 9, 1997

8/987406

Gene H. Barnett - Gates Mills OH

The Cleveland Clinic Foundation - Cleveland OH

A61B 600

600429

An interventionalist or operator uses a variety of apparatus 30 including tools, tool guides, and pointers in a procedure on a region of interest. The region of interest was previously the subject of a diagnostic imaging procedure to generate three dimensional diagnostic image data, selective slices or other portions of which are displayable on video monitors 34. The position of the apparatus 30 in operator space is determined by actuating emitters 32, receiving the emitted signals with receivers 12, and calculating the position of the pointer in operator space. A pair of radio translucent constructions 14, 16 each carry a plurality of radiopaque markers 18 which are positioned adjacent the region of interest. Two or more projection images are taken through the region of interest and the radiopaque markers using a movable x-ray tube 22 and radiation detector 24. The operator uses a control 36 to position cursors on corresponding anatomical markers in both the projection images and images from the diagnostic data to determine a correlation or transform between projection image space and diagnostic data space.

6011987, Jan 4, 2000

Dec 8, 1997

8/986863

Gene H. Barnett - Gates Mills OH

The Cleveland Clinic Foundation - Cleveland OH

A61B 500

600414

A fiducial positioning cup (86) has a hemispherical well (92) in its top and a central bore (94) from a bottom of the hemispherical well (92) to a base of the positioning cup (86). The fiducial cup (86) is then attached to the skin (88) of a patient. A needle (110) is passed through the fiducial positioning cup (86) to mark an area of the patient's skin (88) with a tattoo (112). Fiducials (84) are secured in the fiducial positioning cups (86). Magnetic resonance or other diagnostic images are taken. Once the images are taken, the fiducials (84) and fiducial positioning cups (86) are removed. The tattoo mark (112) remains. The fiducial positioning cups (86) are reattached when a stereotactic procedure is to be performed. The needle (110) is passed through the fiducial cups (86) and a tip of the needle (110) is aligned with the tattooed mark (112) on the patient's skin (88). The fiducial cup (86) is then lowered and centered over the tattooed mark (112).

5980535, Nov 9, 1999

Sep 23, 1997

8/935796

Gene H. Barnett - Gates Mills OH
Christopher H. Wood - Bellevue WA
Patrick A. Dayton - Monroe Falls OH

Picker International, Inc. - Highland Heights OH

A61B 1700

606130

A position signaling is usable in connection with an image guided surgery system. A plurality of infrared emitters are mounted on a reference object. The reference object is in turn attached to the rocker arm of a head clamp. The head clamp includes a frame and a first head engaging pin secured to one side of the frame. The rocker arm includes two head engaging pins and is movable in relation to the frame. The image guided surgery system uses the signals provided by the infrared emitters to determine and account for movement of the patient's head.