GARY M. KUPFER
Medical Practice at Lee St, Charlottesville, VA
License number
Virginia 0101058469
Category
Medical Practice
Type
Pediatrics
Address
Address
Lee St, Charlottesville, VA 22908
Phone
(434) 924-0000
Personal information
See more information about GARY M. KUPFER at radaris.comName
Address
Phone
1277 Mountain Rd, Charlottesville, VA 22901
Professional information
Htlv-I Tax Induced Killing Of P53 Null Cancer Cells
US Patent:
2005021, Sep 29, 2005
Filed:
May 16, 2003
Appl. No.:
10/514475
Inventors:
Oliver Semmes IV - Newport News VA, US
Gary Kupfer - Charlottesville VA, US
Gary Kupfer - Charlottesville VA, US
International Classification:
A61K048/00, C12N015/867
US Classification:
435456000, 424093200, 514027000, 514034000, 514283000, 514251000, 514449000, 514548000, 424649000
Abstract:
This invention is based on the finding that expression of an exogenous nucleic acid encoding a polypeptide having human T-cell leukemia virus type I (HTLV-1) Tax activity in p53 null cells results in a sensitization of those cells to DNA damaging agents. Therefore, the present invention is directed to a method of inducing cell death in p53 null cells, enhancing susceptibility to such DNA damaging agents, and the selective cell killing of p53 null cells. It has been found that retroviral vectors, and particularly lentiviral vectors, are suitable for the present invention to permit the transient expression of the HTLV-1 Tax protein in the p53 null cells, which sensitizes the cells.
Medical Practice licenses in Virginia
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