Inventors:
Thomas P. Segerson - Portland OR
J. Mark Kinzie - Portland OR
Eileen R. Mulvihill - Mercer Island WA
Julie A. Saugstad - Portland OR
Gary L. Westbrook - Portland OR
Assignee:
ZymoGenetics, Inc. - Seattle WA
State of Oregon, acting by and through the Oregon State Board of Higher
Education on behalf of the Oregon Health Sciences University
International Classification:
C12Q 168, C07H 2102, C07H 2104
Abstract:
Metabotropic receptor mGluR7 is identified and sequenced. The mGluR7 receptor subfamily mediates inhibition of transmitter release at selected glutamatergic synapses. The receptors, mGluR7-specific peptides and antibodies thereto are used to identify agonists and antagonists of G protein coupled glutamate receptor mediated neuronal transmitter release, as well as in methods of diagnosis and therapy.