GARY ARTHUR SILVERMAN
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD424838
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15224
Personal information
See more information about GARY ARTHUR SILVERMAN at radaris.comName
Address
Phone
500 Regatta Dr UNIT 2526, Philadelphia, PA 19146
95 Quail Hill Rd, Blawnox, PA 15238
236 Madison St, State College, PA 16801
Professional information
Dr. Gary A Silverman, Pittsburgh PA - MD (Doctor of Medicine)
Specialties:
Neonatal Medicine
Address:
Magee Womens Hosp Neonatology
300 Halket St, Pittsburgh 15213
(412) 641-4111 (Phone)
300 Halket St, Pittsburgh 15213
(412) 641-4111 (Phone)
Certifications:
Pediatrics, 1988, Perinatal Medicine & Neonatal Medicine, 2004
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
Magee Womens Hosp Neonatology
300 Halket St, Pittsburgh 15213
Magee-Womens Hospital of UPMC
300 Halket St, Pittsburgh 15213
Upmc Mercy
1400 Locust St, Pittsburgh 15219
300 Halket St, Pittsburgh 15213
Magee-Womens Hospital of UPMC
300 Halket St, Pittsburgh 15213
Upmc Mercy
1400 Locust St, Pittsburgh 15219
Education:
Medical School
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Graduated: 1984
Childrens Hospital
St Louis Chldns Hosp Wash U
Washington U Sch Med/Lab Stanley Korsmeyer
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Graduated: 1984
Childrens Hospital
St Louis Chldns Hosp Wash U
Washington U Sch Med/Lab Stanley Korsmeyer
Gary Silverman, Pittsburgh PA
Work:
Neonatal Medicine
300 Halket St, Pittsburgh, PA 15213
300 Halket St, Pittsburgh, PA 15213
Methods Of Treating Disorders Associated With Protein Aggregation
US Patent:
2013002, Jan 24, 2013
Filed:
May 3, 2012
Appl. No.:
13/463638
Inventors:
Stephen C. Pak - Pittsburgh PA, US
David Hirsch Perlmutter - Pittsburgh PA, US
Gary A. Silverman - Pittsburgh PA, US
David Hirsch Perlmutter - Pittsburgh PA, US
Gary A. Silverman - Pittsburgh PA, US
Assignee:
University of Pittsburgh - of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A61K 31/454, A61P 25/16, A61K 31/5415, A61K 31/138, A01K 67/033, A61K 31/34, A61K 31/704, A61K 31/545, C07H 21/00, A61K 49/00, A61P 25/28, A61K 31/337
US Classification:
800 3, 514322, 5142258, 514646, 514449, 514468, 514 27, 514209, 536 235, 800 9, 800 12
Abstract:
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein aggregate (“APA”) compound selected from the group consisting of pimozide, fluphenazine (e.g., fluphenazine hydrochloride), tamoxifen (e.g., tamoxifen citrate), taxol, cantharidin, cantharidic acid, salts thereof and their structurally related compounds. It is based, at least in part, on the discovery that each of the aforelisted compounds were able to promote degradation of aggregated ATZ protein in a model system. According to the invention, treatment with one or more of these APA compounds may be used to ameliorate the symptoms and signs of AT deficiency as well as other disorders marked by protein aggregation, including, but not limited to, Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease.
Automated High-Content Live Animal Drug Screening Using C. Elegans
US Patent:
2011015, Jun 23, 2011
Filed:
Sep 14, 2010
Appl. No.:
12/881976
Inventors:
Stephen C. Pak - Pittsburgh PA, US
David H. Perlmutter - Pittsburgh PA, US
Gary A. Silverman - Pittsburgh PA, US
David H. Perlmutter - Pittsburgh PA, US
Gary A. Silverman - Pittsburgh PA, US
International Classification:
G01N 33/00, C07H 21/04, C12N 15/63, A01K 67/00
US Classification:
800 3, 536 231, 4353201, 800 13, 800 9, 800 12
Abstract:
The present invention relates to methods and compositions for high content drug screening in which may be used to identify compounds that treat disorders associated with protein aggregation.