Inventors:
Garrett M. Brodeur - Philadelphia PA
Akira Nakagawara - Philadelphia PA
Assignee:
Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
A61K 39395, C12Q 168, C12P 1934, C07H 2102
Abstract:
The amino acid sequence of the full length version of the human neurotrophic factor receptor TRK B and a nucleotide sequence encoding it are disclosed. Transformed host cells and transgenic animals containing nucleic acid molecules encoding full length human TRK-B are disclosed. Probes, primers and antisense molecules identical and complementary to the nucleotide sequence that encodes full length human TRK-B, particularly the intracellular portion of the receptor are disclosed. Monoclonal antibodies that bind to the full length human TRK-B protein are disclosed. Methods of using and kits which include probes, primers, antisense molecules and monoclonal antibodies are disclosed.